April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Effect of trabeculectomy and canaloplasty on intraocular pressure modifications after postural changes in primary open-angle glaucoma
Author Affiliations & Notes
  • Ivano Riva
    Center for the Study of Glaucoma, University of Brescia, Brescia, Italy
  • Luciano Quaranta
    Center for the Study of Glaucoma, University of Brescia, Brescia, Italy
  • Elena Biagioli
    Laboratory of Clinical Research, IRCCS - Istituto di Ricerche Farmacologiche “Mario Negri”, Milano, Italy
  • Claudia Tosoni
    Ophthalmology Department, A.O. San Maria della Misericordia, Udine, Italy
  • Paolo Brusini
    Ophthalmology Department, A.O. San Maria della Misericordia, Udine, Italy
  • Andreas Katsanos
    Ophthalmology Department, University of Ioannina, Ioannina, Greece
  • Irene C Floriani
    Laboratory of Clinical Research, IRCCS - Istituto di Ricerche Farmacologiche “Mario Negri”, Milano, Italy
  • Anastasios-Georgios Konstas
    Glaucoma Unit, 1st University Department of Ophthalmology, AHEPA Hospital, Thessaloniki, Greece
  • Footnotes
    Commercial Relationships Ivano Riva, None; Luciano Quaranta, None; Elena Biagioli, None; Claudia Tosoni, None; Paolo Brusini, None; Andreas Katsanos, None; Irene Floriani, None; Anastasios-Georgios Konstas, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 3160. doi:
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      Ivano Riva, Luciano Quaranta, Elena Biagioli, Claudia Tosoni, Paolo Brusini, Andreas Katsanos, Irene C Floriani, Anastasios-Georgios Konstas; Effect of trabeculectomy and canaloplasty on intraocular pressure modifications after postural changes in primary open-angle glaucoma. Invest. Ophthalmol. Vis. Sci. 2014;55(13):3160.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

The present study investigated the effect of trabeculectomy (TE) and canaloplasty (CP) upon the posture-induced intraocular pressure (IOP) changes in patients with primary open-angle glaucoma (POAG).

 
Methods
 

This observational study was conducted on patients with bilateral POAG who had undergone successful TE with Mitomycin C, or CP in one eye for at least 1 year. The IOP was measured first in a sitting position and thereafter in supine position. Absolute change of sitting IOP before and after surgery was calculated and compared for each surgical group, and between groups. The pressure change from sitting to supine position was evaluated and compared between groups.

 
Results
 

Twenty-six POAG patients were enrolled in each surgical group. Mean post-operative sitting IOP was 10.2 mm Hg (SD 2.3) and 14.9 mm Hg (SD 2.7) in the TE and CP groups respectively (p<0.0001). The relative increase in supine IOP was greater in the CP group (28.4%, SD 13.7) with an absolute difference of 4.3 mm Hg (SD 1.9), compared with the TE group (18.1%, SD 11.4) with an absolute difference of 1.7 mm Hg (SD 0.9); (p=0.005). (Table 1, Figure 1)

 
Conclusions
 

The current study shows that TE is more effective than CP in reducing IOP variations between sitting and supine position. It is important to consider postural changes in IOP while managing glaucoma patients, especially those requiring a greater IOP reduction or at a greater risk of glaucoma progression.

   
 
Figure 1: Postural changes of IOP after canaloplasty and trabeculectomy
 
Figure 1: Postural changes of IOP after canaloplasty and trabeculectomy
 
Keywords: 568 intraocular pressure • 458 circadian rhythms  
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