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Sarah Read, Mehreen Adhi, Daniela Ferrara, Jay S Duker, Nadia K Waheed, ; Morphology and Vascular Layers of the Choroid in Stargardt’s Disease Analyzed Using Spectral Domain Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2014;55(13):3349.
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Stargardt’s disease (STGD) is the most common inherited retinal disease. Choroidal angiopathy may be involved in the pathogenesis of Stargardt’s disease. Spectral-domain optical coherence tomography (SD-OCT) is increasingly being used to analyze the choroid in healthy and diseased eyes. This study aimed to examine the total thickness, morphology and individual vascular layers of the choroid in eyes with Stargardt’s disease using SD-OCT.
A retrospective review identified patients with STGD and healthy subjects who underwent 1-line raster scanning using a Cirrus SD-OCT between November 2009 and September 2012.
The choroid in eyes with STGD showed a number of morphological characteristics that differed from healthy controls, including an irregular shape in 26 of 41 (64%) eyes with STGD compared to 0 of 30 (0.0%) healthy eyes (Figure 1). Mean sub-foveal total choroidal thickness and mean sub-foveal large choroidal vessel layer thickness were significantly reduced in eyes with STGD (p=0.03 and p=0.04 respectively, Figure 2a). The maximal choroidal thickness was sub-foveal in only 9 of 41 (22%) eyes and focal choroidal thinning was observed in 21 of 41 (51%) of eyes with STGD. An attenuation of the large choroidal vessel layer was observed in 8 of 41 (20%) eyes with STGD and these eyes had significantly worse visual acuity (p=0.007, Figure 2b).
This study shows that alterations in the total thickness, morphology and the individual vascular layers of the choroid are visible on SD-OCT in eyes with STGD. It also suggests that an enhanced attenuation of the large choroidal vessel layer may have an effect on visual function in eyes with STGD. These findings may potentially contribute to staging and monitoring of STGD.
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