April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Chromatic Full-field Stimulus Threshold (FST) in Proliferative Diabetic Retinopathy
Author Affiliations & Notes
  • Andre Messias
    Ophthalmology, University of Sao Paulo, Ribeirao Preto, Brazil
  • Katharina Messias
    Ophthalmology, University of Sao Paulo, Ribeirao Preto, Brazil
  • Rafael Saran Arcieri
    Ophthalmology, University of Sao Paulo, Ribeirao Preto, Brazil
  • Fabiano Sakamoto
    Ophthalmology, University of Sao Paulo, Ribeirao Preto, Brazil
  • Vinicius M Castro
    Ophthalmology, University of Sao Paulo, Ribeirao Preto, Brazil
    Universitat of Tuebingen, Tübingen, Germany
  • Rodrigo Jorge
    Ophthalmology, University of Sao Paulo, Ribeirao Preto, Brazil
  • Footnotes
    Commercial Relationships Andre Messias, None; Katharina Messias, None; Rafael Arcieri, None; Fabiano Sakamoto, None; Vinicius Castro, None; Rodrigo Jorge, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 335. doi:
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      Andre Messias, Katharina Messias, Rafael Saran Arcieri, Fabiano Sakamoto, Vinicius M Castro, Rodrigo Jorge; Chromatic Full-field Stimulus Threshold (FST) in Proliferative Diabetic Retinopathy. Invest. Ophthalmol. Vis. Sci. 2014;55(13):335.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To describe chromatic full-field stimulus threshold (FST) outcomes in proliferative diabetic retinopathy (PDR) and their relationship with electroretinography (ERG).

Methods: Data from 24 patients with PDR (n=31 eyes; 56 ± 10 years of age; 50% male) were analyzed. Patients were submitted to measurement of best-corrected visual acuity (BCVA), and full field Electroretinography (ERG), according to ISCEV was performed to determine a- and b-wave amplitude and implicit time for dark-adapted rod (0.01 cd.s/m2), combined response (CR: 3.0 cd.s/m2) and light-adapted cone (3.0 cd.s/m2) and 30 Hz flicker (3.0 cd.s/m2). FST was psychophysically determined before ERG recordings, after 25 minutes dark adaptation, using Espion E2 system with the ColorDome LED full-field stimulator (Diagnosys LLC, Lowell, MA), first using red (635 to 638 nm), then blue (465 to 470 nm), and then white (6500 K) stimulus, with 5 minutes inter-session interval. Normal subjects were evaluated to serve as controls (n=20).

Results: Mean ± SE patients’ FST was significantly higher than (controls’) for white: -28.1 ± 1.3 dB (-42.3 ± 0.7 dB; ANOVA P<0.001), blue: -33.9 ± 1.7 dB (-48.9 ± 0.7 dB; P<0.001); and red: -14.6 ± 0.9 dB (-25.4 ± 0.6 dB; P<0.001). Of interest, only 7 (23%), 6 (19%) and 11 (35%) eyes were above the controls’ 5% quantile. Mean BCVA was 0.40 ± 0.05 logMAR (range: 20/20 to 20/200), and was not significantly correlated to FST of any color. There was moderate (r ≥ 0.5) significant (P<0.05) correlation between white FST and dark-adapted b-wave amplitude and implicit time.

Conclusions: These data indicate that FST is sensitive for retinal functional changes due to proliferative diabetic retinopathy, and might add interesting information about visual function in clinical trials including these patients.

Keywords: 688 retina • 507 electrophysiology: clinical • 499 diabetic retinopathy  
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