April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Evaluation of choroidal thickness by SD-OCT and Enhanced Depth Imaging in patients with chronic central serous chorioretinopathy (CSC) and their relatives
Author Affiliations & Notes
  • Mathieu Lehmann
    Hotel Dieu de Paris, Paris cedex 04, France
  • Min Zhao
    Hotel Dieu de Paris, Paris cedex 04, France
  • Antoine P Brezin
    Hotel Dieu de Paris, Paris cedex 04, France
  • Francine F Behar-Cohen
    Hotel Dieu de Paris, Paris cedex 04, France
  • Footnotes
    Commercial Relationships Mathieu Lehmann, None; Min Zhao, None; Antoine Brezin, None; Francine Behar-Cohen, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 3353. doi:
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      Mathieu Lehmann, Min Zhao, Antoine P Brezin, Francine F Behar-Cohen; Evaluation of choroidal thickness by SD-OCT and Enhanced Depth Imaging in patients with chronic central serous chorioretinopathy (CSC) and their relatives. Invest. Ophthalmol. Vis. Sci. 2014;55(13):3353.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: The aim of this study is to evaluate the subfoveal choroidal thickness (SFCT) in patients with chronic Central Serous Chorioretinopathy (CSC), and their relatives.

Methods: Five patients with chronic CSC (diffuse retinal pigment epitheliopathy) and 16 of their relatives were examined. Ophthalmologic examination included assessment fundus autofluorescence and OCT combined with Enhanced Depth Imaging (EDI). Sufoveolar Choroidal Thickness (SCT) ≥ 395µm was considered as thickened. Three groups of patients were defined by the phenotype of the fundus: 0 = normal fundus appearance; 1 = suspected CSC (pigment epithelial detachment and / or retinal pigment epithelium atrophy); 2 = CSC.

Results: Five families were included. The mean SCT (42 eyes) was 396.56±113.3µm, (range: 179 - 800). It was significantly greater in the group 2 and 1, versus group 0 (448.1±126.7µm versus 361,6±89.86 µm, p=0.038). Among the 32 eyes of relatives, 7 were suspected of CSC (22%) and 16 had a thickened subfoveal choroid (50%); nine of them had a normal fundus (28%).

Conclusions: This study shows that 50% of relatives of patients with CSC have the phenotype: “thickened subfoveal choroid ≥ 395µm”. This inheritable trait could allow CSC to develop, depending on other triggering events.

Keywords: 688 retina • 452 choroid • 552 imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound)  
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