April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
White dots as a novel marker of diabetic retinopathy severity in ultrawide field imaging
Author Affiliations & Notes
  • Yoko Dodo
    Opthalmology, Kyoto University Graduate School of Medicine, Kyoto, Japan
  • Tomoaki Murakami
    Opthalmology, Kyoto University Graduate School of Medicine, Kyoto, Japan
  • Noriyuki Unoki
    Opthalmology, Kyoto University Graduate School of Medicine, Kyoto, Japan
  • Ken Ogino
    Opthalmology, Kyoto University Graduate School of Medicine, Kyoto, Japan
  • Akihito Uji
    Opthalmology, Kyoto University Graduate School of Medicine, Kyoto, Japan
  • Shin Yoshitake
    Opthalmology, Kyoto University Graduate School of Medicine, Kyoto, Japan
  • Nagahisa Yoshimura
    Opthalmology, Kyoto University Graduate School of Medicine, Kyoto, Japan
  • Footnotes
    Commercial Relationships Yoko Dodo, None; Tomoaki Murakami, None; Noriyuki Unoki, None; Ken Ogino, None; Akihito Uji, None; Shin Yoshitake, None; Nagahisa Yoshimura, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 3411. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Yoko Dodo, Tomoaki Murakami, Noriyuki Unoki, Ken Ogino, Akihito Uji, Shin Yoshitake, Nagahisa Yoshimura; White dots as a novel marker of diabetic retinopathy severity in ultrawide field imaging. Invest. Ophthalmol. Vis. Sci. 2014;55(13):3411.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: Diabetic retinopathy (DR) is often accompanied with well-demarcated smaller white dots in the sensory retina, although its relevance remains ill-defined. We thus evaluated the association of white dots with the severity of DR and the nonperfusion areas in fluorescein angiography (FA) images using ultrawide field scanning laser ophthalmoscope (Optos200Tx®).

Methods: We retrospectively reviewed 125 eyes of 77 patients with DR on whom ultrawide field photograph was obtained using Optos200Tx®. We selected at random 25 eyes of individual categories in international classification of DR severity (no apparent retinopathy, mild nonproliferative diabetic retinopathy [NPDR], moderate NPDR, severe NPDR, and proliferative diabetic retinopathy [PDR]). White dots were fine and well-demarcated, and delineated with higher signal levels on green laser (532 nm) images but not on red laser (633 nm) images. We counted them using ultrawide field photograph, and evaluated the association of white dots with DR severity.

Results: The numbers of white dots were 8.6±9.7, 3.9±4.9, 3.7±4.9, and 2.3±3.5 in the superonasal, inferonasal, superotemporal, and inferotemporal quadrants respectively in 100 eyes with DR. Eyes with DR had larger number of white dots than those with no apparent retinopathy (18.5±17.7 vs. 2.5±2.8, p<0.001). The number of white dots in eyes with moderate NPDR (17.7±16.0, p=0.030), severe NPDR (21.8±21.1, p<0.001), or PDR (28.0±17.9, p<0.001) was significantly larger than that in eyes with mild NPDR (6.3±4.0). There was a positive correlation between the number of white dots and the number of intraretinal hemorrhages in 100 eyes with DR (r=0.453, p<0.001). Thirty-two eyes with intraretinal microvascular abnormality (IRMA) had more white dots than 68 eyes without IRMA (25.4±20.1 vs. 15.2±15.6, p=0.005), although there were no differences in number of white dots between eyes with or without venous beading (20.6±14.8 vs. 18.0±18.4, p=0.138).

Conclusions: These data suggest that white dots delineated by ultrawide field photograph are related to the severity of DR.

Keywords: 499 diabetic retinopathy  
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×