April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Comparison of Three Power Levels of A Novel Soft Contact Lens Optical Design to Reduce Suspected Risk Factors for the Progression of Juvenile Onset Myopia.
Author Affiliations & Notes
  • Sally M Dillehay
    Visioneering Technologies Inc, Alpharetta, GA
  • Jill Woods
    School of Optometry, University of Waterloo, Waterloo, ON, Canada
  • Ping Situ
    School of Optometry, University of Waterloo, Waterloo, ON, Canada
  • Sarah Guthrie
    School of Optometry, University of Waterloo, Waterloo, ON, Canada
  • Rick Edward Payor
    Visioneering Technologies Inc, Alpharetta, GA
  • Richard A Griffin
    Visioneering Technologies Inc, Alpharetta, GA
  • Mark Tyson
    Visioneering Technologies Inc, Alpharetta, GA
  • Lyndon William Jones
    School of Optometry, University of Waterloo, Waterloo, ON, Canada
  • Footnotes
    Commercial Relationships Sally Dillehay, Visioneering Technologies Inc (E); Jill Woods, Visioneering Technologies Inc. (F); Ping Situ, Visioneering Technologies Inc. (F); Sarah Guthrie, Visioneering Technologies Inc. (F); Rick Payor, Visioneering Technologies Inc. (C); Richard Griffin, Visioneering Technologies Inc. (C), Visioneering Technologies Inc. (I), Visioneering Technologies Inc. (P), Visioneering Technologies Inc. (S); Mark Tyson, Visioneering Technologies Inc. (E), Visioneering Technologies Inc. (I); Lyndon Jones, Visioneering Technologies Inc. (F)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 3637. doi:
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      Sally M Dillehay, Jill Woods, Ping Situ, Sarah Guthrie, Rick Edward Payor, Richard A Griffin, Mark Tyson, Lyndon William Jones; Comparison of Three Power Levels of A Novel Soft Contact Lens Optical Design to Reduce Suspected Risk Factors for the Progression of Juvenile Onset Myopia.. Invest. Ophthalmol. Vis. Sci. 2014;55(13):3637.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

The intent of incorporating therapeutic optical designs into the vision correction for myopia is to retard further myopia progression (MP). This study tests the feasibility to alter suspected risk factors using 3 levels of a novel optical design in soft contact lenses (SCLs).

 
Methods
 

Twenty children 9 to 15 yrs. (median 13) were enrolled in a double-masked, bilateral study wearing the three Test (T) SCLs for 2 hours each. The lenses were lathe-cut, polymacon 38%, 8.3mm basecurve and 14.5 mm diameter. T lenses had a continuously increasing positive power starting from the center and extending into the periphery of the optical zone (US Patents 6474814 and 7178918). The increase in positive power was T1 < T2 < T3. The outcome measures were distance and near high and low contrast visual acuity (VA), an abbreviated Pediatric Refractive Error Profile (aPREP) quality of life score, a series of vision intensive tasks and subjective ratings (SRs), amplitude (near point push-up, AofA) and lag of accommodation by dynamic retinoscopy (LofA-DR) and by auto-refraction (LofA-A), and peripheral auto-refraction (Grand Seiko WAM-5500, PR).

 
Results
 

All 20 subjects completed the study. There were no statistically significant differences in VAs; all differences were < 2 letters; <0.04 logMAR. There were statistically significant differences in aPREP scores, with T3 < T1 on the overall score (65 vs. 75; p<0.01). Some SRs were lower for T3 than T1 (87 vs. 95/100; p<0.01 and 88 vs. 95/100; p<0.02). AofA differences were small, and only T2 was significantly > T1 (12.2 vs. 11.6D; p<0.03). LofA-DR decreased from T1 to T3 (0.47, 0.45, 0.32D), T3 < T1 p<0.02 RE). LofA-A means were higher than using the previous LofA-DR method, T1 to T3 (0.74, 1.16, 1.06D). LofA-A for T1 < T2 (p<0.02). PRs with all test lenses showed systematic increases in minus refraction (various positions; p<0.05 paired-t) compared with the central refraction normalized baseline PRs.

 
Conclusions
 

Increasing the power level of optical designs tested in this study decreased the LofA-DR and decreased the hyperopic PR; both suspected risk factors for MP. Small but significant reductions in visual performance were found as the power level of optical designs increased. Further studies are warranted to test these optical designs as an inhibitor against the progression of juvenile-onset myopia.

     
Keywords: 605 myopia • 477 contact lens • 677 refractive error development  
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