April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Association between GAS7 genetic variant and primary open-angle glaucoma in the Japanese population
Author Affiliations & Notes
  • Fumihiko Mabuchi
    Ophthalmology, University of Yamanashi, Chuo, Japan
  • Yoichi Sakurada
    Ophthalmology, University of Yamanashi, Chuo, Japan
  • Seigo Yoneyama
    Ophthalmology, University of Yamanashi, Chuo, Japan
  • Kenji Kashiwagi
    Ophthalmology, University of Yamanashi, Chuo, Japan
  • Zentaro Yamagata
    Health Sciences, University of Yamanashi, Chuo, Japan
  • Hiroyuki Iijima
    Ophthalmology, University of Yamanashi, Chuo, Japan
  • Footnotes
    Commercial Relationships Fumihiko Mabuchi, None; Yoichi Sakurada, None; Seigo Yoneyama, None; Kenji Kashiwagi, None; Zentaro Yamagata, None; Hiroyuki Iijima, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 3821. doi:
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      Fumihiko Mabuchi, Yoichi Sakurada, Seigo Yoneyama, Kenji Kashiwagi, Zentaro Yamagata, Hiroyuki Iijima; Association between GAS7 genetic variant and primary open-angle glaucoma in the Japanese population. Invest. Ophthalmol. Vis. Sci. 2014;55(13):3821.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: It was reported that the growth arrest-specific 7 (GAS7) genetic variants were associated with intraocular pressure (IOP) and primary open-angle glaucoma (POAG) in the Caucasian population. This study was performed to assess whether the GAS7 genetic variant was associated with IOP and POAG in the Japanese population.

Methods: Four hundred and twenty-five Japanese patients with POAG, including normal tension glaucoma (NTG, n=213) and high tension glaucoma (HTG, n=212) and 191 control subjects without glaucoma were analyzed for the GAS7 genetic variant (rs11656696). The genotype and allele frequencies were compared between the patients with NTG or HTG and the control subjects. Maximum known IOP in all participants was compared between each genotype.

Results: No significant differences of the genotype and allele frequencies were observed between the patients with NTG (CC: 22.5%, AC: 50.7%, AA: 26.8%, P=0.34; C allele: 47.9%, A allele: 52.1%, P=0.23) or HTG (CC: 21.7%, AC: 47.6%, AA: 30.7%, P=0.38; C allele: 45.5%, A allele: 54.5%, P=0.57) and the control subjects (CC: 16.8%, AC: 53.4%, AA: 29.8%, C allele: 43.5%, A allele: 56.5%). There were no significant differences (P=0.34, analysis of variance) of the maximum IOPs among CC (21.4 ± 8.7mmHg, mean ± standard deviation), AC (20.4 ± 7.1mmHg), and AA (21.3 ± 8.8mmHg) genotypes.

Conclusions: Association between the GAS7 genetic variant and IOP or POAG was not found in the Japanese population.

Keywords: 539 genetics  
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