April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Clinical Relevance of Gram Positive Endophthalmitis and Antibiotic Susceptibility
Author Affiliations & Notes
  • Rebecca Shields
    Ophthalmology, Bascom Palmer Eye Institute, Miami, FL
  • Harry W Flynn
    Ophthalmology, Bascom Palmer Eye Institute, Miami, FL
  • Darlene Miller
    Ophthalmology, Bascom Palmer Eye Institute, Miami, FL
  • Footnotes
    Commercial Relationships Rebecca Shields, None; Harry Flynn, None; Darlene Miller, Department of Defense (F), NIH Center Core Grant P3OEYO4801 (F), Research to Prevent Blindness Unrestricted Grant (F)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 3858. doi:
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      Rebecca Shields, Harry W Flynn, Darlene Miller; Clinical Relevance of Gram Positive Endophthalmitis and Antibiotic Susceptibility. Invest. Ophthalmol. Vis. Sci. 2014;55(13):3858.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: The purpose of this study is to report the spectrum of gram-positive organisms causing culture-proven endophthalmitis and their susceptibilities to current antibiotics.

Methods: Medical records were reviewed of all cases with culture-proven endophthalmitis at a single institution from January 2012 to September 2013. The outcome measures included all intravitreal isolates identified as well as antibiotic susceptibilities.

Results: A total of 30 gram positive organisms were isolated from vitreous specimens during the study period. The most common organisms identified were the following: Staphylococcus epidermidis 60% (18/30); Streptococcus viridians and Streptococcus pneumonia 6.7% (2/30); Staphylococcus aureus 13.3% (4/30), Streptococcus mitis and Staphylococcus hominis 3.3% (1/30). For these organisms, overall susceptibilities were the following: vancomycin, 92.08 % (25/30 organisms susceptible); gentamicin, 90.9% (23/30 organisms susceptible); sulfamethoxazole/trimethoprim, 75.9% (25/30 organisms susceptible); linezolid 100% (27/30 organisms susceptible); moxifloxacin 47.68% (27/30 organisms susceptible); erythromycin 41.75% (24/30 organisms susceptible); ciprofloxacin 47.5% (23/30 organisms susceptible). Staphylococcus epidermis demonstrated the overall highest MICs, specifically in regards to Vancomycin, when compared to other organisms.

Conclusions: The current study demonstrates resistance to commonly used medications. Future concerns regarding increased resistance among the most common isolated organisms are demonstrated when compared to a historical pattern.

Keywords: 513 endophthalmitis • 422 antibiotics/antifungals/antiparasitics  
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