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Rebecca Shields, Harry W Flynn, Darlene Miller; Clinical Relevance of Gram Positive Endophthalmitis and Antibiotic Susceptibility. Invest. Ophthalmol. Vis. Sci. 2014;55(13):3858.
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The purpose of this study is to report the spectrum of gram-positive organisms causing culture-proven endophthalmitis and their susceptibilities to current antibiotics.
Medical records were reviewed of all cases with culture-proven endophthalmitis at a single institution from January 2012 to September 2013. The outcome measures included all intravitreal isolates identified as well as antibiotic susceptibilities.
A total of 30 gram positive organisms were isolated from vitreous specimens during the study period. The most common organisms identified were the following: Staphylococcus epidermidis 60% (18/30); Streptococcus viridians and Streptococcus pneumonia 6.7% (2/30); Staphylococcus aureus 13.3% (4/30), Streptococcus mitis and Staphylococcus hominis 3.3% (1/30). For these organisms, overall susceptibilities were the following: vancomycin, 92.08 % (25/30 organisms susceptible); gentamicin, 90.9% (23/30 organisms susceptible); sulfamethoxazole/trimethoprim, 75.9% (25/30 organisms susceptible); linezolid 100% (27/30 organisms susceptible); moxifloxacin 47.68% (27/30 organisms susceptible); erythromycin 41.75% (24/30 organisms susceptible); ciprofloxacin 47.5% (23/30 organisms susceptible). Staphylococcus epidermis demonstrated the overall highest MICs, specifically in regards to Vancomycin, when compared to other organisms.
The current study demonstrates resistance to commonly used medications. Future concerns regarding increased resistance among the most common isolated organisms are demonstrated when compared to a historical pattern.
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