April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
A Retrospective Case Study of the Incidence of Endogenous Fungal Endophthalmitis in Patients with Positive Blood Cultures for Systemic Fungemia: Review of the Literature
Author Affiliations & Notes
  • Katherine Chen
    University of Chicago, Chicago, IL
  • Juner Colina
    University of Chicago, Chicago, IL
  • Laura Snyder
    University of Chicago, Chicago, IL
  • Seenu M Hariprasad
    University of Chicago, Chicago, IL
  • Footnotes
    Commercial Relationships Katherine Chen, None; Juner Colina, None; Laura Snyder, None; Seenu Hariprasad, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 3859. doi:
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      Katherine Chen, Juner Colina, Laura Snyder, Seenu M Hariprasad; A Retrospective Case Study of the Incidence of Endogenous Fungal Endophthalmitis in Patients with Positive Blood Cultures for Systemic Fungemia: Review of the Literature. Invest. Ophthalmol. Vis. Sci. 2014;55(13):3859.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To determine the incidence of fungal ocular involvement, which can manifest as chorioretinitis or endophthalmitis, in patients with positive fungal blood cultures in a tertiary care center.

 
Methods
 

Retrospective case series and literature review. 100 adult and pediatric inpatients with positive fungal blood cultures.From August 1st, 2006 to October 31st, 2009, inpatient consultations at University of Chicago were evaluated for fungal ocular involvement. Patients were evaluated for the presence or absence of ocular involvement of fungal organisms on clinical exam.

 
Results
 

Ophthalmology was consulted on 100 patients with fungemia and only one patient had clinical signs of ocular involvement (1/100, 1%). That patient had blood cultures positive for Candida glabarata, did not have ocular symptoms, and clinically improved after switching antifungal therapy to PO voriconazole. Two patients had nonspecific fundus lesions that were not consistent with chorioretinitis or endophthalmitis. In decreasing order of frequency, Candida albicans, Candida parapsilosis, Candida glabarata, Candida lusitaniae, Candida tropicalis, and others were the organisms identified in the blood cultures.

 
Conclusions
 

The incidence of ocular involvement in patients with fungemia is 1% in this study, which is consistent with recent trends in literature. We believe that there needs to be revised guidelines and criteria in screening at-risk inpatients for fungal chorioretinitis and endophthalmitis.

   
 
Comparison of Similar Studies. *autopsy patients.
 
Comparison of Similar Studies. *autopsy patients.
 
Keywords: 530 fungal disease • 513 endophthalmitis • 451 chorioretinitis  
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