April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
: En Face OCT Patterns of choriocapillaris and of different choroidal vascular layers and their changes in active polypoidal choroidal vasculopathy.
Author Affiliations & Notes
  • Gabriel J Coscas
    Department of Ophthalmology, Creteil Eye Clinic Univ Hospital, Creteil, France
  • Florence Coscas
    Department of Ophthalmology, Creteil Eye Clinic Univ Hospital, Creteil, France
  • Ali Dirani
    Department of Ophthalmology, Creteil Eye Clinic Univ Hospital, Creteil, France
  • Oudy Semoun
    Department of Ophthalmology, Creteil Eye Clinic Univ Hospital, Creteil, France
  • Eric H Souied
    Department of Ophthalmology, Creteil Eye Clinic Univ Hospital, Creteil, France
  • Footnotes
    Commercial Relationships Gabriel Coscas, allergan (C), bayer (C), novartis (C); Florence Coscas, allergan (C), Bayer (C), novartis (C); Ali Dirani, None; Oudy Semoun, None; Eric Souied, allergan (C), bayer (E), novartis (C), thea (C)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 3865. doi:
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      Gabriel J Coscas, Florence Coscas, Ali Dirani, Oudy Semoun, Eric H Souied; : En Face OCT Patterns of choriocapillaris and of different choroidal vascular layers and their changes in active polypoidal choroidal vasculopathy.. Invest. Ophthalmol. Vis. Sci. 2014;55(13):3865.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To assess with En Face OCTcharacteristic patterns of choriocapillaris and of different choroidal vascular layers and their changes in eyes with active polypoidal choroidal vasculopathy (PCV), treated with combined PDT-Ranibizumab (R*).

Methods: retrospective study of 61 consecutive patients (32females) with PCV in the subfoveal region, treated for active PCV. Visual acuity (BCVA), ICGA, FA and En Face EDI-OCT were obtained. The central macular and subfoveal choroidal thickness were evaluated before and after treatment. Patterns of choriocapillaris, of choroidal vascular layer, presence of hyper reflective dots in retina and in choroid, were assessed on OCT.. The results will be compared with a group of 10 healthy subjects.

Results: En Face OCT of choriocapillaris, of choroid and of any abnormal choroidal vascular network (AVN) will be shown. The mean follow up was 7.34±9.22 months. After treatment, 73% of eyes gained visual acuity or remained stable and 28% of eyes lost one line or more on EDTRS scale. CMT decreased significantly from 352.62±117.04 um at presentation to 302.95±77.77 um at last follow up visit (p=0.012). SFCT decreased significantly (from280.33±101.60 um to 223.65±100.50 um)- p=0.001). BCVA changed from 0.50±0.28 log MAR to 0.44±0.28 log MAR (p=0.764).Retinal and choroidal hyper reflective dots decreased significantly (p=0.001). The leakage decreased significantly (p= 0, 05). The number of polyps and AVN seen on ICGA did not change significantly after treatment (p=0.99 and p=1 respectively). The number of choroidal layers and of dilated choroidal layers did not change significantly after treatment (p=0.375 - p=0.5 respectively).

Conclusions: : En Face OCT patterns of choriocapillaris, of choroidal vascular layers, and of any AVN could be specifically recognized and analyzed. Treatment PDT + R* of PCV resulted in stabilization or improvement of VA in 73% of treated eyes. This treatment resulted in significant decrease in CMT and SFCT, in hyper reflective retinal and choroidal dots but the number of choroidal layers and dilated choroidal layers did not change. These anatomical characteristics changes after treatment could be reliable indices to monitor the effect of treatment in PCV.

Keywords: 552 imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • 452 choroid  
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