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Ravi Keshavamurthy, Sandeep Grover, K V Chalam; Correlation between foveal ischemia and spectral-domain optical coherence tomography findings in retinal vein occlusion. Invest. Ophthalmol. Vis. Sci. 2014;55(13):3892.
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To investigate the relationship between size of the foveal avascular zone (FAZ) and structural changes on spectral-domain optical coherence tomography (SD-OCT) in patients with retinal vein occlusion.
This was a retrospective, cross-sectional study including 30 eyes of 30 patients with retinal vein (central vein, n=16, and branch retinal vein, n=14) occlusion and ischemic maculopathy as determined by irregular margins of the FAZ in fluorescein angiography. Fellow eyes (without any retinal pathology) were used as controls. FAZ (delineated on SD-OCT, Spectralis) as well as central subfield thickness (CST) and subfoveal volume (SFV, volume within 1 mm diameter circle centered on fovea) were measured . FAZ was correlated with CST, SFV and best-corrected visual acuity (BCVA).
The mean FAZ was significantly higher in the study eyes (1.28 + 1.21 mm2) compared to the control eyes (0.65 + 0.33 mm2, p=0.008). The mean CST and SFV were 357.47 ± 161.31 μm and 0.28 ± 0.13 mm3, respectively, in the study eyes, which was significantly different from the control eyes(p=0.01). FAZ correlated significantly with change in SFV in both patients with CVO and BRVO (r= -0.62 and r= 0.71, respectively). No significant correlation was seen between FAZ and BCVA.
Foveal avascular zone correlates significantly with change in central subfield thickness and subfoveal volume on SD-OCT during acute phase in patients with retinal vascular occlusion.
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