April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Do Intrinsic Photosentive Ganglion Cells (ipRGC) Really Project to the Dorsal Midbrain? Color Pupillography in Patients with Pretectal Lesions
Author Affiliations & Notes
  • Helmut Wilhelm
    Ophthalmology, University eye hospital, Tuebingen, Germany
  • Fumiatsu Maeda
    Ophthalmology, University eye hospital, Tuebingen, Germany
  • Tobias Peters
    Ophthalmology, University eye hospital, Tuebingen, Germany
  • Barbara Wilhelm
    Ophthalmology, University eye hospital, Tuebingen, Germany
  • Footnotes
    Commercial Relationships Helmut Wilhelm, None; Fumiatsu Maeda, None; Tobias Peters, None; Barbara Wilhelm, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 4111. doi:
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      Helmut Wilhelm, Fumiatsu Maeda, Tobias Peters, Barbara Wilhelm, ; Do Intrinsic Photosentive Ganglion Cells (ipRGC) Really Project to the Dorsal Midbrain? Color Pupillography in Patients with Pretectal Lesions. Invest. Ophthalmol. Vis. Sci. 2014;55(13):4111.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: Patients with a lesion of the dorsal midbrain usually show the following findings: 1. Bilaterally absent pupillary light reaction 2. Preserved near response 3. Upgaze palsy (most pronounced for saccades) 4. Preserved vestibular ocular reflex Actually, the pupillary light response is not completely absent. Using a strong light, the pupil constricts slowly. It could be shown that pupillary responses to gratings and colour patterns were the same as in normal subjects.

Methods: We had the possibility to examine 4 patients with a profound lesion of the superior colliculi caused by a mass lesions that had been surgically. They had all the symptoms mentioned above. We examined her with colour pupillography using the following stimuli: Red 605±20 nm, 4 s duration, 28 lux; blue 420±20 nm, 4 s duration, 28 lux and compared to averaged data from 17 normal subjects.

Results: Pupil constriction to the red stimulus ranged from 4 to 23% related to baseline diameter (average 14.5%, in normal subjects average 40.1%). Pupil response to the blue stimulus ranged from 28 to 49% (average 39.1%, in normals 54.0%). This means that the red response was reduced by 64% whereas the blue response was only reduced by 28%, i.e. much less affected.

Conclusions: As we suppose that the blue stimulus addressed the ipRGC it must be assumed that their pathway to the midbrain somehow might bypass the pretectal area.

Keywords: 667 pupil • 612 neuro-ophthalmology: diagnosis • 668 pupillary reflex  
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