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Sara Brittingham, Christoph Tappeiner, Beatrice E Frueh; Demarcation line after cross-linking using two different treatment protocols. Invest. Ophthalmol. Vis. Sci. 2014;55(13):4222.
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© ARVO (1962-2015); The Authors (2016-present)
To compare the occurrence of a demarcation line after corneal cross-linking (CXL) for keratoconus using two different protocols (standard versus rapid protocol with higher intensity and shorter irradiation time).
A retrospective analysis on an interventional case series of 119 progressive keratoconus eyes treated with CXL using the standard Dresden protocol (30min irradiation, 3mW/cm2, UV-XTM 1000) or a rapid protocol (10min irradiation, 9 mW/cm2, UV-XTM 2000) was performed. The presence of a corneal demarcation line was assessed with anterior segment OCT (Heidelberg Spectralis) one month after treatment by a masked observer.
In the standard protocol group, 65% (58/89) of treated corneas revealed a demarcation line one month after cross-linking, whereas such a demarcation line was observed in only 20% (6/30) of eyes treated with rapid protocol.
Increasing UV intensity and reducing irradiation time for CXL has a negative effect on the occurrence of the demarcation line one month after the procedure. Further studies are needed to evaluate the effect on keratoconus progression.
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