April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
The Relationship between Intraocular Pressure and the Peripapillary Retinal Nerve Fiber Layer Thickness in Chinese Americans without Eye Disease: The Chinese American Eye Study
Author Affiliations & Notes
  • Thasarat S Vajaranant
    UIC, Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, Chicago, IL
  • Shaung Wu
    UIC, Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, Chicago, IL
  • Chunyi Hsu
    UIC, Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, Chicago, IL
  • Mina Torres
    UIC, Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, Chicago, IL
  • Rohit Varma
    UIC, Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, Chicago, IL
  • Footnotes
    Commercial Relationships Thasarat Vajaranant, None; Shaung Wu, None; Chunyi Hsu, None; Mina Torres, None; Rohit Varma, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 4279. doi:
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      Thasarat S Vajaranant, Shaung Wu, Chunyi Hsu, Mina Torres, Rohit Varma, ; The Relationship between Intraocular Pressure and the Peripapillary Retinal Nerve Fiber Layer Thickness in Chinese Americans without Eye Disease: The Chinese American Eye Study. Invest. Ophthalmol. Vis. Sci. 2014;55(13):4279.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To explore the relationship between intraocular pressure (IOP) on the peripapillary retinal nerve fiber layer (pRNFL) thickness in Chinese Americans without any evidence of eye disease.

Methods: We analyzed data from the CHES, the first population-based study of 4582 Chinese-Americans aged 50 years and older in Monterey Park, California. The participants completed a comprehensive eye exam including measurements of the pRNFL thickness by the Cirrus SD-OCT. Participants with glaucoma, age-related macular degeneration, diabetic retinopathy, and high myopia (> 6 diopters) were excluded from this analysis. One eye from each participant was randomly selected for this analysis. Linear regression models were used to determine the relationship of age, sex, hypertension, diabetes, axial length (AL), spherical equivalent, IOP, central corneal thickness, and ocular perfusion pressure on the pRNFL thickness.

Results: The final analysis included one eye of 3961 participants with a mean age of 61.5±8.9 years (63.8% females). In this cohort, the mean IOP was 15.2 ± 2.9 mmHg, and the mean global pRNFL thickness was 94.6 ± 13.2 µm. Thinner pRNFL was associated with older age (p <.0001); being male (p = 0.01); having hypertension (p = 0.04); having type 2 diabetes (p < .0001); longer AL (p < .0001); more myopic refractive error (p < .0001); and higher IOP (p <.0001). For every decade of older age, the pRNFL is thinner by 3.5 µm (95% confidence interval (CI), 3.0-4.0 µm). With every 10-mmHg-increase in IOP, the pRNFL is thinner by 2.7 µm (95% CI, 1.5-4.0).

Conclusions: Our findings represent the first epidemiologic analyses of the pRNFL thickness in the Chinese Americans without eye disease. Given that higher IOP was associated with thinner pRNFL, IOP may need to be taken into account when assessing the pRNFL thickness for diagnosis and follow-up of glaucoma.

Keywords: 464 clinical (human) or epidemiologic studies: risk factor assessment • 550 imaging/image analysis: clinical  
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