April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Dietary intake of polyunsaturated fatty acid and diabetic retinopathy in well-controlled diabetes
Author Affiliations & Notes
  • Mariko Sasaki
    Department of Ophthalmology, Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne University, Melbourne, VIC, Australia
    Department of Ophthalmology, Keio University, Sibuya-ku, Japan
  • Ryo Kawasaki
    Department of Ophthalmology, Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne University, Melbourne, VIC, Australia
    Department of Public Health, Yamagata University Faculty of Medicine, Yamagata, Japan
  • Sophie Rogers
    Department of Ophthalmology, Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne University, Melbourne, VIC, Australia
  • Ryan Man
    Department of Ophthalmology, Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne University, Melbourne, VIC, Australia
  • Katsumasa Itakura
    Department of Ophthalmology, Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne University, Melbourne, VIC, Australia
  • Jing Xie
    Department of Ophthalmology, Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne University, Melbourne, VIC, Australia
  • Victoria Flood
    Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, Sydney, NSW, Australia
  • Kazuo Tsubota
    Department of Ophthalmology, Keio University, Sibuya-ku, Japan
  • Ecosse Luc Lamoureux
    Department of Ophthalmology, Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne University, Melbourne, VIC, Australia
    Singapore Eye Research Institute, National University of Singapore, Singapore, Singapore
  • Jie Jin Wang
    Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, Sydney, NSW, Australia
  • Footnotes
    Commercial Relationships Mariko Sasaki, None; Ryo Kawasaki, None; Sophie Rogers, None; Ryan Man, None; Katsumasa Itakura, None; Jing Xie, None; Victoria Flood, None; Kazuo Tsubota, None; Ecosse Lamoureux, None; Jie Jin Wang, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 4392. doi:
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      Mariko Sasaki, Ryo Kawasaki, Sophie Rogers, Ryan Man, Katsumasa Itakura, Jing Xie, Victoria Flood, Kazuo Tsubota, Ecosse Luc Lamoureux, Jie Jin Wang; Dietary intake of polyunsaturated fatty acid and diabetic retinopathy in well-controlled diabetes. Invest. Ophthalmol. Vis. Sci. 2014;55(13):4392.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To assess the associations of dietary intake levels of polyunsaturated fatty acid (PUFA) with diabetic retinopathy (DR) in patients with well-controlled diabetes.

Methods: Patients with diabetes were recruited from a tertiary eye hospital in Melbourne. After excluding non-responders to a dietary survey or patients without optimal fundus image quality, 434 patients (median age; 66 years old) were included for this analysis. Dietary intake was assessed using a Food Frequency Questionnaire. PUFA (combined omega-3 and -6) were adjusted for total energy intake (kcals) using the residuals method. The association between PUFA intake quartile and DR was assessed using logistic regression models and is expressed as odds ratios (ORs) and 95% confidence intervals (CI).

Results: After adjusting age, gender, HbA1c (%) and duration of diabetes (years), well-controlled diabetic patients (HbA1c <= 7%, n=137) in the 4th intake quartile of PUFA were less likely to have DR, compared to the 1st quartile (OR 0.18, 95% CI: 0.05-0.59, p=0.005). A significant trend of decreasing ORs for DR associated with increasing PUFA intake quartiles was noted (p for trend = 0.017). There was no significant association between PUFA intake and DR among poorly-controlled diabetic patients (HbA1c < 7%, n=281).

Conclusions: We found in this sample that increase in PUFA intake could be associated with reduced DR in well-controlled diabetic patients. Prospective studies are needed to confirm the observed association, and if so, reveal the mechanisms of the protective effect of PUFA on diabetic complications.

Keywords: 499 diabetic retinopathy • 498 diabetes • 618 nutritional factors  
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