April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Intravitreal ranibizumab for Vitreous hemorrhage in Proliferative Diabetic Retinopathy
Author Affiliations & Notes
  • Ali Dirani
    Ophtalmology, Saint-Joseph University, Faculty of Medecine, Beirut, Lebanon
    Ophtalmology, Eye Ear International Hospital, Naccache, Lebanon
  • Ali Fadlallah
    Ophtalmology, Saint-Joseph University, Faculty of Medecine, Beirut, Lebanon
    Ophtalmology, Eye Ear International Hospital, Naccache, Lebanon
  • George Azar
    Ophtalmology, Eye Ear International Hospital, Naccache, Lebanon
  • Elias Chelala
    Ophtalmology, Saint-Joseph University, Faculty of Medecine, Beirut, Lebanon
  • Joseph Nehme
    Ophtalmology, Eye Ear International Hospital, Naccache, Lebanon
  • Ramzi Alameddine
    Ophtalmology, American University of Beirut, Beirut, Lebanon
  • Alexandre Jalkh
    Ophtalmology, Saint-Joseph University, Faculty of Medecine, Beirut, Lebanon
  • Footnotes
    Commercial Relationships Ali Dirani, None; Ali Fadlallah, None; George Azar, None; Elias Chelala, None; Joseph Nehme, None; Ramzi Alameddine, None; Alexandre Jalkh, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 4395. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Ali Dirani, Ali Fadlallah, George Azar, Elias Chelala, Joseph Nehme, Ramzi Alameddine, Alexandre Jalkh, ; Intravitreal ranibizumab for Vitreous hemorrhage in Proliferative Diabetic Retinopathy. Invest. Ophthalmol. Vis. Sci. 2014;55(13):4395.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: The aim of our study is to investigate the effect of ranibizumab on a cohort of patients with vitreous hemorrhage with respect to change in visual acuity, rate of vitrectomy and rate of recurrence; as compared to a control group treated with observation alone.

Methods: This is a prospective cohort study that included a cohort of real-life patients with presumed PDR who presented with persistent vitreous hemorrhage (> 2 weeks duration) to Eye and Ear University hospital between June 2006 and June 2010. Patients were randomized to two groups: “Ranibizumab group” was treated with intravitreal injections of ranibizumab and “Control group” was observed closely for spontaneous resolution. VH was also graded into mild/moderate and severe according to its density and extent. In both groups, vitrectomy was carried out if there was no improvement in the VH after 3 months. In the “Ranibizumab group”, intravitreal injection of ranibizumab was repeated if there was an improvement of VA at the one month follow up visit or if there was partial clearing of vitreous hemorrhage as evidenced by fundus examination.

Results: 133 patients were included in the study. 71 patients were in the group A (mean age 67.9±10.2) and 62 patients were in the group B ( mean age 69.4±8.5) . Cumulative probability of vitrectomy by 16 weeks was 24% with ranibizumab group vs 35% with Control group (p= 0.144). Recurrence of VH occurred within 16 weeks in 31% % and 47 %, in Ranibizumab group and Control group respectively. (P= 0.06). There was a significant difference in the cumulative probability of vitrectomy by 16 weeks in patients with mild-moderate VH between ranibizumab and Control groups (16% and 39% respectively; p= 0.04). The cumulative probability of vitrectomy by 16 weeks in patients with severe VH was similar between ranibizumab and Control groups ( 30% and 32 % respectively; p= 0.831). Also, this study found consistently better visual acuity in the ranibizumab group at 2, 4, 12 and 16 weeks post op compared to the control group.

Conclusions: In our study, the need for vitrectomy was lower in patients with mild to moderate VH in the ranibizumab group as compared to control group. Intravitreal ranibizumab injection could be considered in patients with VH in PDR especially if the VH is mild to moderate.

Keywords: 499 diabetic retinopathy • 763 vitreous • 561 injection  
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×