April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Different concentrations of aqueous cytokines according to optical coherence tomographic patterns in patients with diabetic macular edema
Author Affiliations & Notes
  • Sung Pyo Park
    Ophthalmology, KangDong Sacred Heart Hospital, Hallym University Medical Center, Seoul, Republic of Korea
  • Jin Young Kim
    Ophthalmology, KangDong Sacred Heart Hospital, Hallym University Medical Center, Seoul, Republic of Korea
    Ophthalmology, Seoul National University College of Medicine, Seoul, Republic of Korea
  • Yong Jin Jeong
    Ophthalmology, KangDong Sacred Heart Hospital, Hallym University Medical Center, Seoul, Republic of Korea
  • Footnotes
    Commercial Relationships Sung Pyo Park, None; Jin Young Kim, None; Yong Jin Jeong, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 4407. doi:
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      Sung Pyo Park, Jin Young Kim, Yong Jin Jeong; Different concentrations of aqueous cytokines according to optical coherence tomographic patterns in patients with diabetic macular edema. Invest. Ophthalmol. Vis. Sci. 2014;55(13):4407.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To evaluate the relationship between various cytokine levels in aqueous humor and diabetic macular edema (DME) patterns determined by optical coherence tomographic (OCT).

 
Methods
 

This prospective, interventional, comparative study examined 76 patients with DME. Ten patients who underwent cataract surgery served as controls. Eyes with DME were divided into four groups, based on OCT patterns of DME, prior to intravitreal bevacizumab injection (IVB). Patterns included sponge-like diffuse retinal thickening (SDRT), cystoid macular edema (CME), serous retinal detachment (SRD), and combined CME and SRD. Visual acuity, central macular thickness (CMT), and aqueous cytokine concentrations of interleukin (IL)-6, IL-8, IL-10, IL-13, monocyte chemo attractant protein-1 (MCP-1), vascular endothelial growth factor (VEGF) were measured. The odds ratio (OR) between aqueous cytokines level and each DME pattern were calculated using multivariate regression analysis.

 
Results
 

After IVB, CMT was reduced in all groups, but the highest reduction ratio occurred in eyes with SDRT and CME. Aqueous analyses showed that VEGF was associated with SDRT and Combined pattern (P = 0.003, OR = 1.043, 95% confidence interval [CI] = 1.015-1.072, P = 0.038, OR = 1.014, 95% CI = 1.014-1.043, respectively). IL-6 and MCP-1 were associated with CME (P < 0.001, OR = 1.025, 95% CI = 1.011-1.039, and P < 0.001, OR = 1.003, 95% CI = 1.001-1.004, respectively). IL-6 was also associated with SRD and Combined pattern (P = 0.045, OR = 1.018, 95% CI = 1.006-1.030, P = 0.031, OR = 1.013, 95% CI = 1.002-1.024, respectively).

 
Conclusions
 

IL-6 is highly associated with CME, SRD, and combined pattern and VEGF is significantly associated with SDRT, CME, and combined pattern. Different cytokines may play an important role in the development of DME subtypes determined by OCT patterns.

 
Keywords: 499 diabetic retinopathy • 585 macula/fovea • 490 cytokines/chemokines  
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