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Dong Ho Park, Jae Pil Shin, In Taek Kim; One Year Follow-up of Macular Ganglion Cell Layer and Peripapillary Retinal Nerve Fiber Layer Thickness Changes after Panretinal Photocoagulation. Invest. Ophthalmol. Vis. Sci. 2014;55(13):4422.
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To assess the changes of ganglion cell-inner plexiform layer (GCIPL) thickness, retinal nerve fiber layer (RNFL) thickness, and central subfield thickness (CST) after panretinal photocoagulation (PRP) in diabetic retinopathy for 1 year.
This prospective, interventional case series study examined 35 patients (35 eyes) undergoing PRP, who were diagnosed with severe nonproliferative diabetic retinopathy to non-high-risk proliferative diabetic retinopathy without macular edema. Macular GCIPL thickness, CST, and peripapillary RNFL thickness were measured by spectral-domain OCT at baseline and then at 1, 3, 6, 9, and 12 months after PRP.
Macular GCIPL and peripapillary RNFL (average and all sections) thickness at each follow-up increased significantly from the baseline (p<0.001, respectively). The average, superior, and inferior RNFL thickness at 12 months after PRP decreased significantly compared to the 1 month post-PRP (p=0.007, p=0.028, and p=0.025). The average GCIPL and temporal RNFL thickness showed a significant correlation at each follow-up (p<0.001, respectively). CST at each follow-up increased significantly from the baseline (p<0.001, respectively).
The macular GCIPL and peripapillary RNFL thickness increased throughout the 1 year post-PRP. Furthermore, the macular GCIPL and temporal RNFL thickness showed a significant correlation throughout the 1 year of follow-up.
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