Purchase this article with an account.
Aldo Vagge, Paola Camicione, Cristina Capris, Carlo Sburlati, Simona Panarello, Carlo Enrico Traverso, Paolo Capris; Choroidal Abnormalities in Neurofimomatosis type 1 detected by Near-Infrared Reflectance Imaging in paediatric population. Invest. Ophthalmol. Vis. Sci. 2014;55(13):4490.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To investigate choroidal abnormalities in paediatric patients with neurofibromatosis type 1 (NF1) detected by near-infrared reflectance (NIR) retinography in order to evaluate diagnostic accuracy.
Prospective case-control study. Seventy-eight paediatric patients with NF1, diagnosed according to the National Institutes of Health (NIH) criteria, and 96 healthy control subjects matched for age were examined. Enrolled patients were under 14 years old. The presence and the number of choroidal abnormalities were investigated by confocal scanning laser ophthalmoscopy.
Seventy-eight patients with NF1 (41 female, 37 male; mean age 8.1±3.5 years), were compared with 96 healthy control subjects ( 42 female, 54 male; mean age 8±3 years). Choroidal abnormalities were observed in 53 (67.9%) of the NF1 patients. As regards the fundus topographical distribution, choroidal abnormalities were more frequent at the posterior pole with a statistically significant correlation between patient age and the number of involved choroidal areas. No choroidal abnormalities were present in the control group. Detection accuracy of choroidal nodules was 70%.
Choroidal abnormalities appearing as bright patchy regions detected by NIR imaging occurred very frequently in paediatric patients affected by NF1. The present study appears to show that NIR used to detect choroidal involvement allows for elevated diagnostic accuracy.
This PDF is available to Subscribers Only