April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Open Eye Corneal Swelling with 1-DAY ACUVUE® DEFINE™ and 1-DAY ACUVUE® DEFINE™ with Lacreon® compared to 1-DAY ACUVUE® MOIST®
Author Affiliations & Notes
  • Amir M Moezzi
    Centre for Contact Lens Research, School of Optometry and Vision Science, University of Waterloo, Waterloo, ON, Canada
  • Jalaiah P Varikooty
    Centre for Contact Lens Research, School of Optometry and Vision Science, University of Waterloo, Waterloo, ON, Canada
  • Marc M. Schulze
    Centre for Contact Lens Research, School of Optometry and Vision Science, University of Waterloo, Waterloo, ON, Canada
  • William Ngo
    Centre for Contact Lens Research, School of Optometry and Vision Science, University of Waterloo, Waterloo, ON, Canada
  • Kathrine E Lorenz
    Johnson & Johnson Vision Care, Inc., Jacksonville, FL
  • Lyndon William Jones
    Centre for Contact Lens Research, School of Optometry and Vision Science, University of Waterloo, Waterloo, ON, Canada
  • Footnotes
    Commercial Relationships Amir Moezzi, None; Jalaiah Varikooty, None; Marc Schulze, None; William Ngo, None; Kathrine Lorenz, Johnson & Johnson Vision Care, Inc. (E); Lyndon Jones, Johnson & Johnson Vision Care, Inc. (F)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 4672. doi:
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      Amir M Moezzi, Jalaiah P Varikooty, Marc M. Schulze, William Ngo, Kathrine E Lorenz, Lyndon William Jones; Open Eye Corneal Swelling with 1-DAY ACUVUE® DEFINE™ and 1-DAY ACUVUE® DEFINE™ with Lacreon® compared to 1-DAY ACUVUE® MOIST®. Invest. Ophthalmol. Vis. Sci. 2014;55(13):4672.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To determine if the use of pigments or adding PVP during the fabrication of 1-DAY ACUVUE® DEFINE™ contact lenses impacts open eye corneal swelling.

Methods: A double-masked, randomized, bilateral crossover study was conducted in 24 Asian subjects using 1-DAY ACUVUE® DEFINE™ (AD), 1-DAY ACUVUE® DEFINE™ with Lacreon® (AL) and 1-DAY ACUVUE® MOIST® (control). Central corneal thickness (CCT) was measured before lens insertion and immediately after lens removal following an 8 ± 1 hour open eye period in one eye, using an optical pachymeter (OP). Corneal thickness in the horizontal meridian was measured along a 10 mm chord in the contralateral eye, using the Visante™ OCT. A test for non-inferiority for each lens relative to the control was carried out for corneal swelling. The corneal endothelial bleb response was measured at baseline and 20 minutes after insertion using a Topcon SP-3000P specular microscope. High contrast VA (HCVA) and subjective grading of limbal and bulbar hyperemia and corneal staining were monitored at each visit.

Results: After 8 ± 1 hours open eye wear, the LS mean differences in central corneal swelling induced by AD and the control were -0.05% (95% CI, -0.28 - 0.18) and 0.17% (95% CI, -0.29 - 0.63%), and between AL and control lens were -0.16% (95% CI, -0.39 - 0.08%) and -0.13% (95% CI, -0.59 - 0.34%) measured with OP and OCT respectively. OCT measurements along the horizontal meridian showed a similar trend, with corneal swelling LS mean differences of 0.27% (95% CI, -0.14 - 0.67%) and 0.04% (95% CI, -0.37 - 0.45%) in peri-central, 0.20% (95% CI, -0.28 - 0.67%) and -0.02% (95% CI, -0.50 - 0.45%) in mid-peripheral, and -0.03 % (95% CI, 0.65 - 0.58%) and -0.26 % (95% CI, -0.87 - 0.36%) in peripheral zone between each AD and AL and control lens respectively. No endothelial blebs were found in this study. The differences between the study lenses in HCVA, limbal and bulbar hyperemia and corneal staining were unremarkable.

Conclusions: After 8 ± 1 hours open eye wear, central and peripheral corneal swelling along horizontal meridian with each AD and AL lens were equal to that observed with the control lens. These results confirm that the addition of PVP or pigments to obtain a limbal ring design have no impact on corneal swelling during normal open eye wear.

Keywords: 477 contact lens • 479 cornea: clinical science  
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