April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
RNFL attenuation coefficients for normal and glaucomatous eyes from standard peripapillary SD-OCT circle scans
Author Affiliations & Notes
  • Gijs Thepass
    Rotterdam Ophthalmic Institue, Rotterdam Eye Hospital, Rotterdam, Netherlands
  • Johannes F de Boer
    Rotterdam Ophthalmic Institue, Rotterdam Eye Hospital, Rotterdam, Netherlands
    Department of Physics and Astronomy, VU Amsterdam, Amsterdam, Netherlands
  • Hans G Lemij
    Glaucoma Service, Rotterdam Eye Hospital, Rotterdam, Netherlands
  • Koenraad Arndt Vermeer
    Rotterdam Ophthalmic Institue, Rotterdam Eye Hospital, Rotterdam, Netherlands
  • Footnotes
    Commercial Relationships Gijs Thepass, Heidelberg Enginering (F); Johannes de Boer, Heidelberg Enginering (F), Patents related to OCT technology (P), Patents related to tissue scattering properties (P); Hans Lemij, Heidelberg Enginering (F); Koenraad Vermeer, General Hospital Corporation (P), Heidelberg Enginering (F)
  • Footnotes
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Investigative Ophthalmology & Visual Science April 2014, Vol.55, 4742. doi:
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      Gijs Thepass, Johannes F de Boer, Hans G Lemij, Koenraad Arndt Vermeer; RNFL attenuation coefficients for normal and glaucomatous eyes from standard peripapillary SD-OCT circle scans. Invest. Ophthalmol. Vis. Sci. 2014;55(13):4742.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

Regular peripapillary SD-OCT circle scans can be used to obtain the attenuation coefficient (AC) of the retinal nerve fiber layer (RNFL). To obtain information based on the strength of the OCT signal, we determined the AC, an optical property derived from scattering and absorption in tissue. (Vermeer, ARVO E-abstract 395, 2013) Our aim was to use a commercially available OCT system and the system’s proprietary fully automated RNFL segmentation to determine the RNFL ACs in a next step. Resulting ACs were evaluated for use of this marker as a new glaucoma diagnostic.

 
Methods
 

Peripapillary circle scans of the Spectralis OCT system (Heidelberg Engineering) were made in 30 normal eyes and in 30 mild (MD 0 to -6 dB), 30 moderate (MD -6 to -12 dB) and 30 advanced (MD <-12 dB), age matched, glaucomatous eyes. The OCT images were converted into depth-resolved AC images in an automated fashion by using our own algorithm. Next, the Spectralis segmentation was used to determine RNFL AC. The RNFL ACs were then compared between the four groups.

 
Results
 

Figure 1 shows a conventional OCT circle scan image and three AC images in a normal and 2 glaucomatous eyes. Figure 2 shows the ACs for all eyes and median values for each group. The connecting line shows the highly significant trend (Jonckheere-Terpstra, p<0.001). There was a statistically significant relationship (p<0.001) between MD and RNFL AC (Spearman ρ=0.529). Between group comparisons showed statistically significant differences (p<0.05) for all groups for RNFL AC, except between normal and mild glaucoma (p=0.209) and between moderate and advanced glaucoma (p=0.117) (Fig.2).

 
Conclusions
 

We used a commercially available OCT system to obtain RNFL ACs. We found a highly statistically significant relationship between RNFL AC and glaucoma severity. These results are consistent with previous work based on manual segmentation (Van der Schoot, IOVS, 2012). By using automated segmentation in a regular OCT system, we have shown the possibility of implementation of our algorithm in a currently used clinical device. Future work will focus on improving the segmentation, excluding blood vessels and adding spatial analysis to improve the performance of our method.

 
 
Figure 1. Standard OCT image and AC images
 
Figure 1. Standard OCT image and AC images
 
 
Figure 2. RNFL ACs for all eyes. All groups differ significantly (p<0.05) except for two (*NS)
 
Figure 2. RNFL ACs for all eyes. All groups differ significantly (p<0.05) except for two (*NS)
 
Keywords: 550 imaging/image analysis: clinical • 610 nerve fiber layer • 630 optical properties  
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