April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Morphometric Stability of the Corneal Sub-basal Nerve Plexus in Healthy Individuals: A 3-year Longitudinal Study Using Corneal Confocal Microscopy
Author Affiliations & Notes
  • Cirous Dehghani
    Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, Australia
  • Nicola Pritchard
    Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, Australia
  • Katie Edwards
    Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, Australia
  • Dimitrios Vagenas
    Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, Australia
  • Anthony W Russel
    School of Medicine, University of Queensland, Woolloongabba, QLD, Australia
    Department of Diabetes and Endocrinology, Princess Alexandra Hospital, Woolloongabba, QLD, Australia
  • Rayaz Malik
    Center for Endocrinology and Diabetes, Institute of Human Development, University of Manchester, Manchester, United Kingdom
  • Nathan Efron
    Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, Australia
  • Footnotes
    Commercial Relationships Cirous Dehghani, None; Nicola Pritchard, None; Katie Edwards, None; Dimitrios Vagenas, None; Anthony Russel, None; Rayaz Malik, None; Nathan Efron, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 4859. doi:
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      Cirous Dehghani, Nicola Pritchard, Katie Edwards, Dimitrios Vagenas, Anthony W Russel, Rayaz Malik, Nathan Efron, ; Morphometric Stability of the Corneal Sub-basal Nerve Plexus in Healthy Individuals: A 3-year Longitudinal Study Using Corneal Confocal Microscopy. Invest. Ophthalmol. Vis. Sci. 2014;55(13):4859.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To examine the age-dependent alterations and the longitudinal course of sub-basal nerve plexus (SNP) morphology in healthy individuals.

Methods: Sixty-four healthy participants had ocular screening, health and metabolic assessment as well as laser-scanning corneal confocal microscopy examination at baseline and at 12-month intervals for three years. At each annual visit, eight central corneal images of the SNP were randomly selected and analysed using a fully-automated analysis system to quantify corneal nerve fibre length (CNFL). Two linear mixed model approaches were fitted to examine the relationship between age and CNFL and the longitudinal changes of CNFL over three years.

Results: At baseline, mean age was 51.9 ± 14.7 years (range, 15 to 75). The cohort was gender balanced (χ2=0.56, p=0.45). Age (t=1.60, p=0.12) and CNFL (t=-0.50, p=0.62) did not differ between genders. Fifty-three participants completed the 36-month visit and 49 participants completed all visits. No significant change in CNFL was observed over the 36-month period (F(1, 55.0)=0.69, p=0.41). Age had a significant effect on CNFL (F(1, 33.2)=5.46, p=0.03) with a linear decrease of 0.05 mm/mm2 in CNFL per one year increase in age (t=-2.3, p=0.03).

Conclusions: CNFL showed a stable course over a 36-month period in healthy individuals, although there was a slight linear reduction in CNFL with age. The findings of this study have implications for understanding the time-course of the effect of pathology and surgical or therapeutic interventions on the morphology of the SNP or suitability of CNFL as a screening/monitoring marker for peripheral neuropathies.

Keywords: 552 imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • 550 imaging/image analysis: clinical  
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