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Clara Lima Afonso, Maria K Oyamada, Kenzo Hokazono, Mario L R Monteiro; Relationship between Pattern electroretinogram, Frequency Domain-OCT and Automated perimetry in Chronic papilledema from Pseudotumor Cerebri Syndrome. Invest. Ophthalmol. Vis. Sci. 2014;55(13):5101.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the ability of transient pattern electroretinogram (PERG) parameters to differentiate between eyes with visual field (VF) loss and resolved papilledema from pseudotumor cerebri syndrome (PTC) and controls, to compare PERG and OCT with regard to discrimination ability, and to assess the correlation between PERG, FD-OCT and VF measurements.
VFs and full-field stimulation PERGs based on both 48 and 14-min checks were obtained from patients with PTC (n=24, 40 eyes) and controls (n=22, 26 eyes). In addition, FD-OCT peripapillary retinal nerve fiber layer (RNFL) and segmented macular layer measurements were obtained and their correlation coefficients were determined.
Compared to controls, PERG N95 and the P50+N95 amplitude measurements with 48-min checks were significantly reduced in eyes with resolved papilledema from PTC. Both PERG N95 amplitude and OCT parameters were able to discriminate papilledema eyes from controls although the macular thickness parameters were more efficient at detecting abnormalities. Significant correlations were found between PERG amplitude values and OCT-measured macular ganglion cell layer and RNFL thickness and total retinal thickness. PERG amplitude was also significantly associated with VF sensitivity loss.
PERG measurements were able to detect neural loss in PTC eyes with a performance comparable to OCT. PERG amplitude measurements were reasonably well correlated with OCT-measured parameters.
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