Purchase this article with an account.
Peter Rasmussen, Sarah E Coupland, Paul T Finger, Enrique O Graue, Hans E Grossniklaus, Penny McKelvie, Kaustubh Mulay, Jan Ulrik Prause, Elisabeth Ralfkiaer, Steffen Heegaard; Prognostication in Ocular Adnexal Lymphoma - Feasibility of the Latest Tumour, Tode, Metastasis Staging System. Invest. Ophthalmol. Vis. Sci. 2014;55(13):5442.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To evaluate the prognostic utility of the tumour, node, metastasis (TNM)-based staging system for primary ocular adnexal lymphomas (i.e. lymphomas arising in the orbit, the eyelids, the conjunctiva, the lacrimal gland and the lacrimal sac) proposed by the American Joint Committee on Cancer.
Retrospective, multicenter study of patients with primary ocular adnexal lymphoma collected from six eye-cancer centers from January 1st 1980 through December 31st 2010.
A total of 578 eligible patients were included in the study, 293 (51%) were females. The median age was 61 years (range 3 - 97 years). The most frequent lymphoma subtypes were: extranodal marginal zone lymphoma (397/578, 69%), follicular lymphoma (63/578, 11%), and diffuse large B-cell lymphoma (52/578, 9%). The TNM-stages were: T1N0M0/conjunctiva (23%), T2N0M0/orbit including the lacrimal gland (67%), T3N0M0/eyelid (6%) and T4N0M0/extension beyond the orbit (2%). For the entire study group the 5-year survival was 73%. The group of patients with diffuse large B-cell lymphoma had a significantly poorer survival compared with extranodal marginal zone lymphoma and follicular lymphoma (5-year survival, 31% vs. 79% vs. 81%, respectively) (log-rank p < 0.01). The survival was not associated with the extension or site-specific location of the lesions as depicted by the TNM-based stages in any of the lymphoma subtypes.
Lymphoma arising in the ocular adnexal region is mainly prevalent in elderly patients. The survival is primarily determined by histopathology rather tumour size or site-specific location.
This PDF is available to Subscribers Only