April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Peripheral hypertrophic subepithelial corneal opacification
Author Affiliations & Notes
  • Gerd Geerling
    Ophthalmology, University of Duesseldorf, Duesseldorf, Germany
  • Marc Schargus
    Ophthalmology, University of Wuerzburg, Wuerzburg, Germany
  • Adrian Gericke
    Ophthalmology, Johannes Gutenberg University Mainz, Mainz, Germany
  • Ursula Schlotzer-Schrehardt
    Ophthalmology, University of Erlangen-Nuernberg, Erlangen, Germany
  • Walter Lisch
    Ophthalmology, Johannes Gutenberg University Mainz, Mainz, Germany
  • Footnotes
    Commercial Relationships Gerd Geerling, None; Marc Schargus, None; Adrian Gericke, None; Ursula Schlotzer-Schrehardt, None; Walter Lisch, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 5459. doi:
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    • Get Citation

      Gerd Geerling, Marc Schargus, Adrian Gericke, Ursula Schlotzer-Schrehardt, Walter Lisch; Peripheral hypertrophic subepithelial corneal opacification. Invest. Ophthalmol. Vis. Sci. 2014;55(13):5459.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To describe bilateral corneal changes in form of limbus parallel circumscribed opacifications .

Methods: 34 patients matching clinical diagnostic criteria were included. 5 patients were treated by superficial keratectomy due to irregular astigmatism induced by the peripheral opacifications. Excised tissues were studied by light and electron microscopy.

Results: All patients were white and all but seven were female. The age range of the study population was 23-83 years, the median age 50 years. There are no other ophthalmologic irregularities or associated systemic abnormalities and no indication of drug-induced keratopathy. The peripheral corneal opacities were whitish-grey, circumscribed,and partially elevated. Sometimes a mild vascularization of the lesion. All of the female patients showed a bright iris. Follow-up mean period was 35 months with no or minimal progression of the corneal changes. Histologically, diffuse subepithelial hyalinosis and focal degenerations of the overlying epithelium were seen.

Conclusions: The etiology of this new entity is unknown. DNA analysis should be performed to in-or exclude a own corneal dystrophy. We also recommend a hormone assay of the female patients including the period of the oral contraceptive use.

Keywords: 479 cornea: clinical science • 482 cornea: epithelium  
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