April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Normal development of central corneal thickness and intra-ocular pressure
Author Affiliations & Notes
  • Ian Cunningham
    Alder Hey Children's NHS Foundation Trust, Liverpool, United Kingdom
  • Arvind Chandna
    Alder Hey Children's NHS Foundation Trust, Liverpool, United Kingdom
  • Footnotes
    Commercial Relationships Ian Cunningham, None; Arvind Chandna, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 5525. doi:
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      Ian Cunningham, Arvind Chandna; Normal development of central corneal thickness and intra-ocular pressure. Invest. Ophthalmol. Vis. Sci. 2014;55(13):5525.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To measure central corneal thickness (CCT) and intra-ocular pressure (IOP) under general anaesthesia for infants under 8 years of age.

 
Methods
 

This study prospectively measured CCT and IOP in 195 Caucasian children attending Alder Hey Children’s Hospital, UK for a surgical procedure unrelated to ophthalmology. Children had no ocular anomalies and underwent general anaesthesia ensuring stable fixation was maintained during IOP and CCT measurements. Children with history of prematurity or other systemic complications were not invited to participate. CCT was measured using a Palmscan pachymeter with a 50Hz ultrasound probe (MicroMedical Devices, USA). IOP was measured by electronic indentation tonometry using Tonopen XL (Reichart, USA).

 
Results
 

Age ranged from 7 weeks to 7and ¼ years (Mean±SD=138±95wks). Over half of children attended for ENT procedures. There was a small trend for CCT to decrease within the first year of life although overall there was no correlation with increasing age (R=-0.0006). There was no statistical difference between right and left CCT so right eye values only were analysed (CCT: t=0.06, df=394, p=0.27; IOP: t=-0.65, df=340, p=0.26). Average CCT was 539±39nm range 470-646nm. Average IOP was 9.8±2.6mmHg range 4 to 18mmHg. There was no correlation between CCT and IOP (R=-0.0025).

 
Conclusions
 

In healthy normally developing children CCT was shown to slightly decrease in the first year of life although there appears to be no consistent growth pattern such as that observed for axial length or anterior chamber depth. It appears there is a large range of corneal thickness in early childhood and it measurement may assist in diagnosing of buphthalmos or infantile glaucoma yet not used in isolation.

 
 
Central corneal thickness (nm) against age (weeks)
 
Central corneal thickness (nm) against age (weeks)
 
 
Central corneal thickness (nm) correlation with intra-ocular pressure (mmHg)
 
Central corneal thickness (nm) correlation with intra-ocular pressure (mmHg)
 
Keywords: 480 cornea: basic science • 497 development • 568 intraocular pressure  
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