April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
3-D epithelial mapping pattern assessment in normal and keratoconus eyes
Author Affiliations & Notes
  • Elana S Rosenberg
    Ophthalmology, New York University School of Medicine, New York, NY
  • Anastasios J Kanellopoulos
    Ophthalmology, New York University School of Medicine, New York, NY
    LaserVision.gr Eye Institute, Athens, Greece
  • George Asimellis
    LaserVision.gr Eye Institute, Athens, Greece
  • Footnotes
    Commercial Relationships Elana Rosenberg, None; Anastasios Kanellopoulos, Alcon (C), Avedro (C); George Asimellis, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 5526. doi:
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      Elana S Rosenberg, Anastasios J Kanellopoulos, George Asimellis; 3-D epithelial mapping pattern assessment in normal and keratoconus eyes. Invest. Ophthalmol. Vis. Sci. 2014;55(13):5526.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To evaluate applicability of spectral domain optical coherence tomography (AS-OCT) of epithelial thickness patterns in normal and in the diagnosis of keratoconus, and to compare with Scheimpflug imaging keratoconus severity.

 
Methods
 

250 healthy (control group-A) and 155 untreated keratoconic (study group-Β) eyes were subjected to anterior segment OCT three-dimensional epithelial thickness imaging. Comparative statistical analysis of patterns was performed, investigating central, minimum, inferior, posterior, and topographic variability of epithelial thickness. Epithelial thickness characteristics were correlated to established Scheimpflug imaging-derived keratoconus classification and anterior surface irregularity indices.

 
Results
 

Intra-individual repeatability of epithelial thickness was for group-A ±1.13 μm, for group-B ±1.78 μm for center and average ±1.67 μm (center, superior, inferior, maximum and minimum). In group-A, center epithelial was 52.54±3.23 μm, maximum 55.33±3.27 μm and minimum 48.50±3.98 μm. In group B, center thickness was 51.75±7.02 μm, maximum and minimum were 63.54±8.85 μm and 40.73±8.51 μm. Topographic variability was 6.07±3.55 μm (range -22.81±12.55 μm) for the keratoconic group-B, while for the control group-A 1.59±0.79 μm (-6.86±3.33 μm). Epithelial thickness topographic variability and range correlated well with keratoconus severity in the study group-B.

 
Conclusions
 

AS-OCT may offer high predictability of 3 dimensional epithelial assessment in keratoconus. Overall epithelial thickness in keratoconic eyes appears significantly different to normal even in lower stages of keratoconus. Increased overall thickness correlated remarkably with keratoconus severity, as defined by established Scheimpflug imaging-derived anterior-surface irregularity indices.

 
 
Examples of epithelial mapping of a normal (left) and a keratoconic patient (right) obtained by Optical Coherence Tomography
 
Examples of epithelial mapping of a normal (left) and a keratoconic patient (right) obtained by Optical Coherence Tomography
 
Keywords: 482 cornea: epithelium • 574 keratoconus • 552 imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound)  
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