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Daniela Domanico, Francesca Verboschi, Chiara Di Crescenzo, Mariella Salomone, Leopoldo Spadea, Enzo M Vingolo; OPEN-ANGLE GLAUCOMA: BCEA and retinal sensitivity compared to Visual Field and RNFL. Invest. Ophthalmol. Vis. Sci. 2014;55(13):5623.
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To evaluate changes in bivariate contour ellipse area (BCEA) and retinal sensitivity in patients with primary open-angle glaucoma compared to visual field data and global retinal nerve fiber layer (RNFL).
43 patients were enrolled (17 male and 26 female), aged between 35 to 80 years ago (mean age 70+11,15) for a total of 86 eyes, with primary open-angle glaucoma in hypotonic treatment with IOP <20 mmHg. All patients had a best corrected visual acuity (BCVA) more than 20/40. Were excluded patients with diabetes, vitreoretinal diseases, media opacities, angle closure glaucoma and chirurgical treatment. All patients were submitted to: Humphrey visual field 30-2 with study of MD (Mean Deviation) and PSD (Pattern Standard Deviation), Spectral Domain Optical Coherence Tomography (SD -OCT, Heidelberg Engineering, Germany) with the study of RNFL, microperimetry MP-1 (Nidek Technologies, Italy) threshold strategy 4-2, Goldmann III stimulus, with fixation study, that was quantified by BCEA (deg2) and retinal sensitivity (dB). The data analysis was conducted using Pearson correlation. The study was conducted from April 2013 to October 2013.
At the end of the study mean BCEA calculated in the first standard deviation (SD) was 1.02+1.57 deg2, mean retinal sensitivity was 13.86+5.11 dB, mean MD was 6.76+6.48 dB and mean PSD was 4.84+3.85 dB, mean global RNFL was 73.79+16.63. Correlation between mean MD and mean BCEA was -0.38 (p=0.0002), correlation between mean PSD and mean BCEA was -0.13 (p=0.216), correlation between mean global RNFL and mean BCEA was -0.31(p=0.004), correlation between mean retinal sensitivity and mean MD was 0.29 (p=0.007), correlation between mean retinal sensitivity and mean PSD was 0.73 (p=0.034), correlation between mean retinal sensitivity and mean global RNFL was 0.28 (0.008).
Results of the study showed that values of retinal sensitivity evaluated with Microperimetry correlated with values of the Visual Field (MD and PSD) and with global RNFL values; while BCEA didn’t showed a correlation with the visual field data and OCT, explained by the typical trend of glaucomatous pathology.
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