April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Pilocarpine Expands Schlemm’s Canal in Normal Subjects
Author Affiliations & Notes
  • Alon Skaat
    Moise and Chella Safra Advanced Ocular Imaging Laboratory, Einhorn Clinical Research Center, New York Eye and Ear Infirmary of the Mount Sinai Health System, New York, NY
  • Sung Chul Park
    Moise and Chella Safra Advanced Ocular Imaging Laboratory, Einhorn Clinical Research Center, New York Eye and Ear Infirmary of the Mount Sinai Health System, New York, NY
    Department of Ophthalmology, New York Medical College, Valhalla, NY
  • Ruojin Ren
    Moise and Chella Safra Advanced Ocular Imaging Laboratory, Einhorn Clinical Research Center, New York Eye and Ear Infirmary of the Mount Sinai Health System, New York, NY
  • Jeffrey M Liebmann
    Moise and Chella Safra Advanced Ocular Imaging Laboratory, Einhorn Clinical Research Center, New York Eye and Ear Infirmary of the Mount Sinai Health System, New York, NY
    Department of Ophthalmology, New York University School of Medicine, New York, NY
  • Robert Ritch
    Moise and Chella Safra Advanced Ocular Imaging Laboratory, Einhorn Clinical Research Center, New York Eye and Ear Infirmary of the Mount Sinai Health System, New York, NY
    Department of Ophthalmology, New York Medical College, Valhalla, NY
  • Footnotes
    Commercial Relationships Alon Skaat, None; Sung Chul Park, Heidelberg Engineering, GmbH (F), Heidelberg Engineering, GmbH (R); Ruojin Ren, None; Jeffrey Liebmann, Carl Zeiss Meditech, Inc (F), Heidelberg Engineering, GmbH (C), Heidelberg Engineering, GmbH (F), Optovue, inc (F), Topcon, Inc (F); Robert Ritch, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 5682. doi:
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    • Get Citation

      Alon Skaat, Sung Chul Park, Ruojin Ren, Jeffrey M Liebmann, Robert Ritch; Pilocarpine Expands Schlemm’s Canal in Normal Subjects. Invest. Ophthalmol. Vis. Sci. 2014;55(13):5682.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To characterize the in vivo effect of pilocarpine on the structure of Schlemm’s canal in normal eyes.

 
Methods
 

Serial horizontal enhanced depth imaging optical coherence tomography (EDI OCT) B-scans of the nasal corneoscleral limbal area were obtained before and one hour after administration of pilocarpine 1% in normal subjects (50 B-scans; interval between scans, ~35 µm). With conjunctival vessels and iris anatomy as landmarks, the same limbal area was scanned before and after pilocarpine administration. Schlemm’s canal was manually delineated in each EDI OCT B-scan. After three-dimensional reconstruction, Schlemm’s canal volume was determined.

 
Results
 

Nine normal eyes (9 subjects; mean age, 32±6 years) were included. The right eye was tested in all subjects. Schlemm’s canal was continuous in the scanned area in all eyes and was successfully delineated (Fig 1) and reconstructed 3-dimensionally. Following pilocarpine 1% administration, mean Schlemm’s canal volume increased by more than 60% (from 15556563±5179705 µm3 to 25501096±11844193 µm3, p=0.04).

 
Conclusions
 

Pilocarpine expands Schlemm’s canal. Whether this results from a direct pilocarpine effect on the canal or secondarily from its effect on the ciliary musculature and/or increased trabecular outflow remains to be determined. EDI OCT of Schlemm’s canal may prove useful in evaluating the mechanisms of action of pharmacologic agents and surgical devices in glaucoma.

 
 
Horizontal EDI OCT B-scan with Schlemm’s canal delineated (green line) before (A) and one hour after (B) administration of pilocarpine 1%.
 
Horizontal EDI OCT B-scan with Schlemm’s canal delineated (green line) before (A) and one hour after (B) administration of pilocarpine 1%.
 
Keywords: 552 imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • 633 outflow: trabecular meshwork • 421 anterior segment  
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