Purchase this article with an account.
Maria de las Mercedes Frick, Carolina Ampuero, Fernanda Pascuet, Bernardo Ariel Schlaen, Matilde Lopez, Erika Miolet Hurtado Jallaza, Agustina Delbene, Cristobal A Couto; Spectral-domain optical coherence tomography imaging in patients with uveitis: Assesment of the integrity of the IS/OS line.. Invest. Ophthalmol. Vis. Sci. 2014;55(13):5812.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To asses the integrity of the highly reflective line representing the junction of photoreceptor inner and outer segment layers (IS/OS) in patients with uveitis and to correlate the findings with visual acuity.
A cross - sectional study was performed to study the integrity of the IS/OS line in 87 eyes of 50 patients with uveitis using spectral-domain OCT imaging. Demografic data was collected. The features of the integrity of the IS/OS line were classified as intact, partially absent or absent. A chi square test was performed to determine the relationship between changes in the IS/OS line and the visual acuity of patients. An Odds Ratio was performed to quantify the relationship between the visual acuity and the IS/OS line group.
OCT data of 35 women and 15 men with a mean age of 40,46 years (r=12-73) and mean follow - up of 48,82 (r= 1-192) were evaluated. The types of uveitis were as follows: 15 patients had Vogt-Koyanagi-Harada disease, 6 multifocal choroiditis, 6 intermediate uveitis, 4 toxoplasmosis, 4 idiopathic uveitis, 3 Fuchs uveitis syndrome, 2 acute anterior uveitis related to HLA B27, 2 esclerouveitis, 1 Behcet syndrome, 1 acute retinal necrosis, 1 herpes anterior uveitis, 1 sarcoidosis, 1 post-vaccinal, 1 tuberculosis, 1 syphilis and 1 rheumatoid arthtritis. Among patients with anterior uveitis only those with posterior involvement were included in this study. BCVA ≤ 20/200 was found in 15 eyes, between 20/50 and 20/100 in 14 eyes and > 20/50 in 58 eyes. According to the IS/OS line, 42 eyes had the Iine without changes (intact), 10 eyes had the line partially absent and 35 had no IS/OS line (absent). The chi square test found a statistically significative relationship between the integrity of the IS/OS line and the BCVA (P <0.001, chi square 36.6, critical value = 18,467). The Odds Ratio between the total absence and the full presence of IS/OS line shows a 32.67 times higher risk to find a BCVA less than or equal to 20/50 in the total absence of the IS/OS line.
In our study, the integrity of the IS/OS line is affected in many patients with uveitis. Moreover, it's integrity is consistent with a good visual acuity.
This PDF is available to Subscribers Only