April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Topographic Choroidal Thickness Analysis of the Macula by Swept Source Optical Coherence Tomography in Unilateral Multifocal Choroiditis
Author Affiliations & Notes
  • Brendan Butler
    Ophthalmology, New York University, New York, NY
    LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, NY
  • Pablo Hernandez-Martinez
    Unit of Macula. Department of Ophthalmology, University and Polytechnic Hospital La Fe, Valencia, Spain
  • Isabel Pascual-Camps
    Unit of Macula. Department of Ophthalmology, University and Polytechnic Hospital La Fe, Valencia, Spain
  • Angélica de Freytas
    Unit of Macula. Department of Ophthalmology, University and Polytechnic Hospital La Fe, Valencia, Spain
  • Maria Andreu-Fenoll
    Unit of Macula. Department of Ophthalmology, University and Polytechnic Hospital La Fe, Valencia, Spain
  • Rosa Dolz-Marco
    Unit of Macula. Department of Ophthalmology, University and Polytechnic Hospital La Fe, Valencia, Spain
  • Jesse J Jung
    Vitreous - Retina - Macula Consultants of New York, New York, NY
    Edward S. Harkness Eye Institute, Columbia University College of Physicians and Surgeons, New York, NY
  • Marcela Marsiglia
    LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, NY
    Edward S. Harkness Eye Institute, Columbia University College of Physicians and Surgeons, New York, NY
  • Sarah Mrejen
    LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, NY
    Vitreous - Retina - Macula Consultants of New York, New York, NY
  • Roberto Gallego-Pinazo
    Unit of Macula. Department of Ophthalmology, University and Polytechnic Hospital La Fe, Valencia, Spain
  • Footnotes
    Commercial Relationships Brendan Butler, None; Pablo Hernandez-Martinez, None; Isabel Pascual-Camps, None; Angélica de Freytas, None; Maria Andreu-Fenoll, None; Rosa Dolz-Marco, Novartis (R), Novartis (S); Jesse Jung, None; Marcela Marsiglia, None; Sarah Mrejen, None; Roberto Gallego-Pinazo, Alcon (C), Alcon (R), Alcon (S), Allergan (S), Bayer (C), Bayer (R), Bayer (S), Carl Zeiss Meditec (R), Heidelberg Engineering (R), Novartis (C), Novartis (R), Novartis (S), Sensimed (S), Thea (S)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 5813. doi:
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      Brendan Butler, Pablo Hernandez-Martinez, Isabel Pascual-Camps, Angélica de Freytas, Maria Andreu-Fenoll, Rosa Dolz-Marco, Jesse J Jung, Marcela Marsiglia, Sarah Mrejen, Roberto Gallego-Pinazo; Topographic Choroidal Thickness Analysis of the Macula by Swept Source Optical Coherence Tomography in Unilateral Multifocal Choroiditis. Invest. Ophthalmol. Vis. Sci. 2014;55(13):5813.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To investigate the choroidal thickness (CT) of the macular area in eyes with unilateral multifocal choroiditis (MFC) in the convalescent stage.

Methods: Consecutive cases with the diagnosis of MFC underwent a comprehensive ophthalmologic examination, best-corrected visual acuity (BCVA), color fundus and autofluorescence photographs, infrared reflectance imaging and swept-source optical coherence tomography. Automated segmentation of the retina and the choroid was used to obtain the corresponding thickness values, and an ETDRS sector grid was applied to compare the choroidal thickness of those sectors affected with choroidal neovascularization (CNV) and those without CNV.

Results: Eleven patients (9 women) with a mean age of 31.77±11.75 were included. The mean±SD time from the onset of visual symptoms related to MFC was 28.9±13.1 months, with a mean of 20.1±10.3 months since the last inflammatory relapse. The mean BCVA was 0.91±0.16 in eyes with MFC and 0.99±0.03 in the fellow eyes (p=0.182). The mean foveal retinal central thickness measured 237.33+/-35.13 and 255.73±18.55 microns respectively (p=0.043); and the mean macular retinal thickness was 269.64±27.07 and 285.58±17.22 microns respectively (p=0.315). The mean subfoveal choroidal thickness was 206.33±41.96 and 234.10±45.95 microns respectively (p=0.190); and the mean macular choroidal thickness was 210.2±33.54 and 239.4±56.97 microns respectively (p=0.280). Areas affected with CNV in 9 of the 11 eyes with MFC did not show any significant difference with respect to areas without CNV in terms of mean choroidal thickness (212.50±27.22 versus 192.46±86.44, p=0.589)

Conclusions: In the present study, retinal and choroidal macular thicknesses were not significantly different between the affected eye and the unaffected fellow eye in patients with unilateral MFC; however, foveal retinal thickness was decreased in the eyes affected with MFC lesions. In addition, macular areas affected with secondary CNV did not show evidence of any significant difference in choroidal thickness when compared with those without CNV.

Keywords: 451 chorioretinitis • 552 imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • 550 imaging/image analysis: clinical  
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