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Wassia Khaja, Kakarla V Chalam, Sandeep Grover; Normative data for intraocular pressure and central corneal thickness in preterm infants. Invest. Ophthalmol. Vis. Sci. 2014;55(13):5913.
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Data for intraocular pressure (IOP) and central corneal thickness (CCT) and the importance of CCT in correcting the IOP readings are available and used in clinical practice. However, not much is known about IOP and CCT data in preterm infants. This study collects normative data for IOP and CCT in preterm infants who were undergoing screening for retinopathy of prematurity (ROP).
During routine ROP screening, subjects underwent an ophthalmic evaluation including: tonometry, portable pachymetry, portable slit-lamp biomicroscopy, and fundus evaluation. Three consecutive measurements were taken with Tono-Pen XL tonometer (Reichert, Inc, Depew, NY), and Pachmate DGH-55 pachymeter (DGH Technology Inc, Exton, PA) and the measurements averaged. By default, the measurements from the right eye only were analyzed.
Twenty-four eyes of 24 infants (14 males, 10 females) were included in this study. The mean gestational age at the time of examination was 34.3 weeks (range, 31.2 - 38.3 weeks ). The mean CCT was 615.72 ± 69.82µm (range, 470 - 793µm ) and mean IOP was 24.28mmHg (range, 13 - 37mmHg). There was a weak, positive correlation between CCT and IOP (r=0.38). Higher IOP was found in African American infants versus Caucasian and Hispanic infants, but there was no statistically significant difference between these races.
Premature newborns, without any obvious eye disease, showed increased IOP values and increased CCT as compared to adults. There was a positive, but weak correlation between IOP and CCT in preterm infants.
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