April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Neonatal serum cytokine profiles with and without retinopathy of prematurity
Author Affiliations & Notes
  • Syatirah Abu Yazib
    Uni Malaya Eye Research Centre, University of Malaya, Kuala Lumpur, Malaysia
  • Rozieyati Mohd Salleh
    School of Health Sciences, Science University of Malaysia, Kubang Kerian, Malaysia
  • Nurliza Khaliddin
    Uni Malaya Eye Research Centre, University of Malaya, Kuala Lumpur, Malaysia
    Department of Ophthalmology, University of Malaya, Kuala Lumpur, Malaysia
  • Yao Mun Choo
    Department of Paediatrics, University of Malaya, Kuala Lumpur, Malaysia
  • Azanna Ahmad Kamar
    Department of Paediatrics, University of Malaya, Kuala Lumpur, Malaysia
  • Sofiah Sulaiman
    Department of Obstetrics and Gynaecology, University of Malaya, Kuala Lumpur, Malaysia
  • May May Choo
    Uni Malaya Eye Research Centre, University of Malaya, Kuala Lumpur, Malaysia
    Department of Ophthalmology, University of Malaya, Kuala Lumpur, Malaysia
  • Chetan K Patel
    Oxford Eye Hospital, John Radcliffe Hospital, Oxford, UK, United Kingdom
  • Tengku A Kamalden
    Uni Malaya Eye Research Centre, University of Malaya, Kuala Lumpur, Malaysia
    Department of Ophthalmology, University of Malaya, Kuala Lumpur, Malaysia
  • Footnotes
    Commercial Relationships Syatirah Abu Yazib, None; Rozieyati Mohd Salleh, None; Nurliza Khaliddin, None; Yao Mun Choo, None; Azanna Ahmad Kamar, None; Sofiah Sulaiman, None; May May Choo, None; Chetan Patel, None; Tengku Kamalden, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 5917. doi:
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      Syatirah Abu Yazib, Rozieyati Mohd Salleh, Nurliza Khaliddin, Yao Mun Choo, Azanna Ahmad Kamar, Sofiah Sulaiman, May May Choo, Chetan K Patel, Tengku A Kamalden, ; Neonatal serum cytokine profiles with and without retinopathy of prematurity. Invest. Ophthalmol. Vis. Sci. 2014;55(13):5917.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To compare serum protein profiles in 3 groups of neonates: those with and without retinopathy of prematurity (ROP) and healthy full term babies.

Methods: Serum were collected from 44 premature babies (22 with ROP and 22 without the disease) between 36 and 38 weeks’ gestation, and from 6 full term babies (at completed 38 weeks’ gestation). The serum concentration of 9 proteins were analyzed using multiplex bead array assay for growth factors.

Results: Differences were noted between the full term and premature babies for scD40L, sFASL and PLGF in the serum, where the levels were significantly lower in premature babies (p<0.05). There was a trend for increased levels of Endoglin and PA-1 and reduced levels of angiopoetin-2 proteins in babies with ROP (p>0.05). There were no differences between the three groups for EGF, uPA or VEGF-C in the serum.

Conclusions: These data shows that differences in growth factors can be detected in the serum of full term babies and premature babies within same gestational period (36-38 weeks), and between premature babies with and without retinopathy. This study suggests that ROP is driven by a diverse range of mechanisms resulting in selective changes in serum growth factor cytokines. Improved understanding of these changes should result in new ways of treating disease.

Keywords: 706 retinopathy of prematurity  
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