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Syatirah Abu Yazib, Rozieyati Mohd Salleh, Nurliza Khaliddin, Yao Mun Choo, Azanna Ahmad Kamar, Sofiah Sulaiman, May May Choo, Chetan K Patel, Tengku A Kamalden, ; Neonatal serum cytokine profiles with and without retinopathy of prematurity. Invest. Ophthalmol. Vis. Sci. 2014;55(13):5917.
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To compare serum protein profiles in 3 groups of neonates: those with and without retinopathy of prematurity (ROP) and healthy full term babies.
Serum were collected from 44 premature babies (22 with ROP and 22 without the disease) between 36 and 38 weeks’ gestation, and from 6 full term babies (at completed 38 weeks’ gestation). The serum concentration of 9 proteins were analyzed using multiplex bead array assay for growth factors.
Differences were noted between the full term and premature babies for scD40L, sFASL and PLGF in the serum, where the levels were significantly lower in premature babies (p<0.05). There was a trend for increased levels of Endoglin and PA-1 and reduced levels of angiopoetin-2 proteins in babies with ROP (p>0.05). There were no differences between the three groups for EGF, uPA or VEGF-C in the serum.
These data shows that differences in growth factors can be detected in the serum of full term babies and premature babies within same gestational period (36-38 weeks), and between premature babies with and without retinopathy. This study suggests that ROP is driven by a diverse range of mechanisms resulting in selective changes in serum growth factor cytokines. Improved understanding of these changes should result in new ways of treating disease.
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