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Anand Vinekar, Parvathi Hari, Amit Zope, Vasudha Kemmanu, Mathew Kurian, Bhujang Shetty, ; Evaluating, monitoring and predicting visual acuity during the first two years of life in premature infants with and without Retinopathy of Prematurity using an indigenous normogram. Invest. Ophthalmol. Vis. Sci. 2014;55(13):5920.
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© ARVO (1962-2015); The Authors (2016-present)
To create a ‘vision normogram’ for evaluation and monitoring of ‘visual acuity milestones’ of premature infants in their first two years of life and evolve statistical formulae to predict vision at two years using clinical and demographic variables of early infancy
161 Asian Indian infants (322 eyes) after completing Retinopathy of Prematurity (ROP) screening at 24 neonatal units were enrolled for vision assessment after exclusion of systemic and ocular co-morbidities. All infants underwent vision assessment using Teller acuity cards (TAC) and cycloplegic refraction six or more times during their first two years of life, including at 3,6,9,12,18 and 24 corrected months of age. Infants were grouped as A (no ROP), B (spontaneously regressed) or C (laser treated ROP with favorable outcome). Linear regression was performed to obtain formulae to predict vision at 24 months
Of the 322 eyes,132,109,81 were in group A, B and C respectively. The visual acuities were comparable between the groups at all 6 study visits (p > 0.05). The mean spherical equivalent (MSE) was comparable until 18 months of age, but at 24 months the lasered group was ‘more myopic’ than the other two groups. (Kruskal Wallis test: p=0.001). Using logistic regression analysis, normograms were plotted for the groups during the study period (Fig 1). Formulae were developed to predict the visual acuity of infants at 24 months, based on criteria available at 3 months of corrected age. Presenting visual acuity at 3 months, birth weight and gestational age were clinical variables used to predict vision at 2 years of age
This study normogram allows clinicians to plot and follow the acuities of infants with and without ROP for the first two years of their lives making it a useful office assessment scale to monitor visual milestones. Predicting vision at two years of age allows prognostic advantages for these infants
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