April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Evaluating, monitoring and predicting visual acuity during the first two years of life in premature infants with and without Retinopathy of Prematurity using an indigenous normogram
Author Affiliations & Notes
  • Anand Vinekar
    Pediatric Retina, Narayana Nethralaya Postgraduate Institute of Ophthalmology, Bangalore, India
  • Parvathi Hari
    Pediatric Retina, Narayana Nethralaya Postgraduate Institute of Ophthalmology, Bangalore, India
  • Amit Zope
    Pediatric Retina, Narayana Nethralaya Postgraduate Institute of Ophthalmology, Bangalore, India
  • Vasudha Kemmanu
    Pediatric Retina, Narayana Nethralaya Postgraduate Institute of Ophthalmology, Bangalore, India
  • Mathew Kurian
    Pediatric Retina, Narayana Nethralaya Postgraduate Institute of Ophthalmology, Bangalore, India
  • Bhujang Shetty
    Pediatric Retina, Narayana Nethralaya Postgraduate Institute of Ophthalmology, Bangalore, India
  • Footnotes
    Commercial Relationships Anand Vinekar, None; Parvathi Hari, None; Amit Zope, None; Vasudha Kemmanu, None; Mathew Kurian, None; Bhujang Shetty, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 5920. doi:
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      Anand Vinekar, Parvathi Hari, Amit Zope, Vasudha Kemmanu, Mathew Kurian, Bhujang Shetty, K.I.D.R.O.P.; Evaluating, monitoring and predicting visual acuity during the first two years of life in premature infants with and without Retinopathy of Prematurity using an indigenous normogram. Invest. Ophthalmol. Vis. Sci. 2014;55(13):5920.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To create a ‘vision normogram’ for evaluation and monitoring of ‘visual acuity milestones’ of premature infants in their first two years of life and evolve statistical formulae to predict vision at two years using clinical and demographic variables of early infancy

 
Methods
 

161 Asian Indian infants (322 eyes) after completing Retinopathy of Prematurity (ROP) screening at 24 neonatal units were enrolled for vision assessment after exclusion of systemic and ocular co-morbidities. All infants underwent vision assessment using Teller acuity cards (TAC) and cycloplegic refraction six or more times during their first two years of life, including at 3,6,9,12,18 and 24 corrected months of age. Infants were grouped as A (no ROP), B (spontaneously regressed) or C (laser treated ROP with favorable outcome). Linear regression was performed to obtain formulae to predict vision at 24 months

 
Results
 

Of the 322 eyes,132,109,81 were in group A, B and C respectively. The visual acuities were comparable between the groups at all 6 study visits (p > 0.05). The mean spherical equivalent (MSE) was comparable until 18 months of age, but at 24 months the lasered group was ‘more myopic’ than the other two groups. (Kruskal Wallis test: p=0.001). Using logistic regression analysis, normograms were plotted for the groups during the study period (Fig 1). Formulae were developed to predict the visual acuity of infants at 24 months, based on criteria available at 3 months of corrected age. Presenting visual acuity at 3 months, birth weight and gestational age were clinical variables used to predict vision at 2 years of age

 
Conclusions
 

This study normogram allows clinicians to plot and follow the acuities of infants with and without ROP for the first two years of their lives making it a useful office assessment scale to monitor visual milestones. Predicting vision at two years of age allows prognostic advantages for these infants

 
 
Fig 1: The vision normogram allows visual acuity assessment and monitoring during the first 2 years of life.The green line denotes the mean visual acuity at each study interval and the two on either side represent 2 standard deviations.
 
Fig 1: The vision normogram allows visual acuity assessment and monitoring during the first 2 years of life.The green line denotes the mean visual acuity at each study interval and the two on either side represent 2 standard deviations.
 
Keywords: 556 infant vision • 757 visual development: infancy and childhood • 677 refractive error development  
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