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Jing Yang, Sheng Zhou, Jianjun Gu; Different Unfolded protein response pathway activation involved in three kinds of cataract. Invest. Ophthalmol. Vis. Sci. 2014;55(13):6029.
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More and more research demonstrated that unfolded protein response is involved in the cataract formation. Since there are so many differences on pathogenesis and clinical manifestation among age related, congenital and high myopia related cataract, the purpose of our experiment is to explore whether UPR is involved in the pathogenesis of these three kinds of cataract, and their UPR pathway activation difference.
Using lens anterior capsular samples from four different groups (normal people, age related cataract, congenital and high myopia related cataract group), we show that the lens exhibited different activation of IRE1, ATF6, and PERK associated UPR pathway among these groups.
Compared with normal people group, high myopia related and age related cataract group have significantly increased IRE1A and EIF2α expression, while congenital cataract group has only significantly increased IRE1A. There was no significant difference of ATF6 expression within the four groups.
Our result indicated that UPR is involved in all of these three kinds of cataract formation, but their activation pathways are variant.
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