April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Risk of Ocular Complications in Non-infectious Uveitis
Author Affiliations & Notes
  • Martha Skup
    AbbVie Inc., North Chicago, IL
  • Namita Tundia
    AbbVie Inc., North Chicago, IL
  • Rachael Sorg
    Analysis Group, Inc, New York, NY
  • Chen Zhao
    Analysis Group, Inc, New York, NY
  • Jingdong Chao
    AbbVie Inc., North Chicago, IL
  • Parvez Mulani
    AbbVie Inc., North Chicago, IL
  • Andrew D Dick
    Bristol Eye Hospital, Bristol, United Kingdom
  • Footnotes
    Commercial Relationships Martha Skup, AbbVie (E), AbbVie (I); Namita Tundia, AbbVie (E), AbbVie (I); Rachael Sorg, AbbVie (F), Analysis Group Inc (E); Chen Zhao, AbbVie (F), Analysis Group (E); Jingdong Chao, AbbVie (E), AbbVie (I); Parvez Mulani, AbbVie (E), AbbVie (I); Andrew Dick, University of Bristol (E)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 6032. doi:
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      Martha Skup, Namita Tundia, Rachael Sorg, Chen Zhao, Jingdong Chao, Parvez Mulani, Andrew D Dick; Risk of Ocular Complications in Non-infectious Uveitis. Invest. Ophthalmol. Vis. Sci. 2014;55(13):6032.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

Non-infectious uveitis (NIU) is characterized by immune-mediated intraocular inflammation that results in ocular complications. Risk of developing ocular complications in privately insured US patients with non-anterior NIU was assessed and compared with matched controls.

 
Methods
 

Patients 18-64 years old with ≥2 non-anterior NIU diagnoses (intermediate-, posterior- or pan-uveitis: ICD-9: 360.12, 362.12, 362.18, 363.0x, 363.10-363.13, 363.15, 363.2x, 364.24) from 01/01/1998 to 03/31/2012 were identified in the OptumHealth claims database. Patients were required to have continuous eligibility ≥6 months before (baseline period) the index date (date of first diagnosis). Non-anterior NIU patients (cases) were matched 1:1 by sex, age, region, company, employment status, and index date to controls without a diagnosis of uveitis. Patients with an ocular complication at baseline were excluded. Risks of developing ocular complications (glaucoma, cataract, visual disturbances, blindness/low vision, retinal detachment or disorders) during the follow-up period were compared using unadjusted Kaplan-Meier log-ranked survival analysis, estimating risk of and time to complications, and adjusted Cox regression analysis, estimating hazard ratios.

 
Results
 

1,769 cases and 1,769 controls met the inclusion criteria (mean age, 47 years; 46.7% male). During the follow-up period, non-anterior NIU patients had a higher risk of any ocular complication (P<.001); the 5-year risk of any ocular complication was 66.4% for patients vs 23.9% for controls (figure, also showing 1- and 10-year complication risks). Specifically, non-anterior NIU patients had a higher risk (P<.001) of glaucoma (5-year: 20.2% vs 9.2%), cataract (5-year: 35.1% vs 13.1%), visual disturbance (5-year: 29.1% vs 8.7%), blindness/low vision (5-year: 4.5% vs 0.5%), retinal detachment (5-year: 10.7% vs 0.8%), and retinal disorder (5-year: 28.1% vs 1.7%). Results were supported by adjusted regression analysis (table).

 
Conclusions
 

Non-anterior NIU is associated with ocular complications such as glaucoma, cataract, visual disturbances, blindness/low vision, retinal detachment or disorders. Optimal treatment initiatives remain imperative to reduce ocular complication-related burden.

   
 
1Blindness/low vision, retinal detachments and retinal disorders were not estimated owing to low event counts.
 
1Blindness/low vision, retinal detachments and retinal disorders were not estimated owing to low event counts.
 
Keywords: 557 inflammation • 745 uvea • 462 clinical (human) or epidemiologic studies: outcomes/complications  
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