April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Is optic neuritis incidence rising? Evidences from an epidemiological study in Barcelona, Spain 2008-2012
Author Affiliations & Notes
  • Elena H Martinez-Lapiscina
    Neurology, IDIBAPS-Hospital Clinic of Barcelona, Barcelona, Spain
  • Elena Fraga-Pumar
    Neurology, IDIBAPS-Hospital Clinic of Barcelona, Barcelona, Spain
  • Xabier Pastor
    Department of Medical Informatics, Hospital Clinic of Barcelona-University of Barcelona, Barcelona, Spain
  • Monica Gómez
    Direction of Strategy and Planning, Hospital Clinic of Barcelona and Technical Office - AISBE, Barcelona, Spain
  • Artur Conesa
    Department of Medical Informatics, Hospital Clinic of Barcelona-University of Barcelona, Barcelona, Spain
  • Raimundo Lozano-Rubí
    Department of Medical Informatics, Hospital Clinic of Barcelona-University of Barcelona, Barcelona, Spain
  • Bernardo Sanchez-Dalmau
    Neurology, IDIBAPS-Hospital Clinic of Barcelona, Barcelona, Spain
    Ophthalmology, IDIBAPS- Hospital Clinic of Barcelona, Barcelona, Spain
  • Alvaro Alonso
    Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN
  • Pablo Villoslada
    Neurology, IDIBAPS-Hospital Clinic of Barcelona, Barcelona, Spain
  • Footnotes
    Commercial Relationships Elena Martinez-Lapiscina, Teva (R); Elena Fraga-Pumar, None; Xabier Pastor, None; Monica Gómez, None; Artur Conesa, None; Raimundo Lozano-Rubí, None; Bernardo Sanchez-Dalmau, Novartis (R); Alvaro Alonso, None; Pablo Villoslada, is He is a shareholder in Bionure Farm (I), Roche, Novartis, MedImmune, TFS, Heidelberg Engineering and Neurotec Farma (R)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 6086. doi:
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      Elena H Martinez-Lapiscina, Elena Fraga-Pumar, Xabier Pastor, Monica Gómez, Artur Conesa, Raimundo Lozano-Rubí, Bernardo Sanchez-Dalmau, Alvaro Alonso, Pablo Villoslada; Is optic neuritis incidence rising? Evidences from an epidemiological study in Barcelona, Spain 2008-2012. Invest. Ophthalmol. Vis. Sci. 2014;55(13):6086.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

Incidence of Optic neuritis (ON) ranges between 0.56-5.1 cases per 100,000 person-years. However, epidemiology of ON has not been updated and there are suggestions that incidence is rising. Considering new therapies for ON, it is important to update epidemiology to design clinical trials and improve health management of ON. We aim to provide prevalence and incidence rates of ON in Barcelona, Spain from 2008 to 2012.

 
Methods
 

Retrospective evaluation of hospital electronic records matching following ICD-9-CM codes: 377.3-optic neuritis, 377.30-optic neuritis, unspecific, 377.31-optic papillitis, 377.32-retrobulbar neuritis, acute, 377.39-other optic neuritis and "optic neuropathy" search-terms. Demographic and clinical data were collected from records with confirmed diagnosis of demyelinating ON, including idiopathic, Multiple Sclerosis and Neuromyelitis Optica origin.

 
Results
 

Prevalence of acute optic neuritis on 31, December 2012 was 2.75 cases per 100,000 people. Mean annual prevalence of acute ON during 2008-2012 periods was 7.87 cases per 100,000 person-years (figure 1A). Mean annual incidence was 5.36 cases per 100,000 person-years (figure 1B). ON recovery was defined as good (high contrast VA > 20/25) for 81% of patients after 12 months of follow up but 4 (5%) patients had VA less than 20/400 which is the VA considered by WHO as blindness criteria. Cumulative probability for MS progression was nearly 30% by 6 months and 45% by the end of follow-up (5 years) (figure 2).

 
Conclusions
 

Incidence of ON in Barcelona during 2008-2012 was higher than previously reported. It may be explained by evolution of diagnosis criteria, use of referral-center approach instead of population-based approach, increased awareness of demyelinating diseases and by possible true increase in its incidence.

     
Keywords: 613 neuro-ophthalmology: optic nerve  
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