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Stanley Darma, Peerooz Saeed, Maarten P Mourits, Michael David Abramoff, Frank D Verbraak; Optical coherence tomography measurements of the macular area in eyes with optic nerve sheath meningioma. Invest. Ophthalmol. Vis. Sci. 2014;55(13):6225.
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© ARVO (1962-2015); The Authors (2016-present)
To explore optical coherence tomography measurements in the macular area as an objective measure of early visual damage in eyes with optic nerve sheath meningioma (ONSM).
In 10 patients diagnosed with unilateral ONSM, SD-OCT volume scans were made of the macular and the optic nerve head area, using Topcon 3D OCT-2000 (Topcon Medical Systems). Peripapillary retinal nerve fiber layer (pRNFL), ganglion cell layer (GCL), ganglion cell - inner plexiform layer (GCIPL) and macular inner retinal layer (mIRL) thickness were measured with the Iowa Reference Algorithm. Patients also underwent visual acuity, color vision and visual field testing. Measurements of the eyes with ONSM were compared with fellow eyes. Statistical testing was performed with Wilcoxon signed rank tests and Spearman correlation tests.
40 OCT scans of 10 eyes with ONSM and 10 fellow eyes were used for analysis. pRNFL, GCL and GCIPL thickness differed significantly between eyes with ONSM and fellow eyes. All three correlated with visual acuity. Mean pRNFL was 50 um vs 96 um; mean GCL was 15 vs 32 um; GCIPL was 48um vs 69um; mean mIRL was 80 vs. 98 um for eyes with ONSM vs. fellow eyes.
pRNFL, GCL and GCIPL are significantly thinner in eyes with ONSM , compared with fellow eyes. The thickness measurements correlated with the visual function and might be used as an objective measure of early visual damage in eyes with ONSM.
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