April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Retinal Vascular Parameters in Dengue Fever
Author Affiliations & Notes
  • Tun Kuan Yeo
    Tan Tock Seng Hospital, Singapore, Singapore
  • David C Lye
    Tan Tock Seng Hospital, Singapore, Singapore
  • Linn Thein Tun
    Tan Tock Seng Hospital, Singapore, Singapore
  • Ling Jun Li
    Singapore Eye Research Institute, Singapore, Singapore
  • Huiqi Huang
    Singapore Eye Research Institute, Singapore, Singapore
  • Carol Cheung
    Singapore Eye Research Institute, Singapore, Singapore
  • Victor Gan
    Tan Tock Seng Hospital, Singapore, Singapore
  • Yee Sin Leo
    Tan Tock Seng Hospital, Singapore, Singapore
  • Stephen C B Teoh
    Tan Tock Seng Hospital, Singapore, Singapore
  • Footnotes
    Commercial Relationships Tun Kuan Yeo, None; David Lye, None; Linn Thein Tun, None; Ling Jun Li, None; Huiqi Huang, None; Carol Cheung, None; Victor Gan, None; Yee Sin Leo, None; Stephen Teoh, None
  • Footnotes
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Investigative Ophthalmology & Visual Science April 2014, Vol.55, 637. doi:
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    • Get Citation

      Tun Kuan Yeo, David C Lye, Linn Thein Tun, Ling Jun Li, Huiqi Huang, Carol Cheung, Victor Gan, Yee Sin Leo, Stephen C B Teoh; Retinal Vascular Parameters in Dengue Fever. Invest. Ophthalmol. Vis. Sci. 2014;55(13):637.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To compare the retinal vascular parameters between patients with acute Dengue Fever infection and healthy normal controls, and to correlate with hematological and biochemical markers.

Methods: This was a prospective case-control study. 64 patients with Dengue infection were recruited and 127 age-gender-ethnicity matched normal healthy controls were selected from a Singapore population-based study. Quantitative retinal vascular parameters (retinal vascular calibre, branching angle, tortuosity and fractal dimension) were measured using a semi-automated computer-based program (Singapore I Vessel Assessment, version 3.0) by trained technicians following a standardized protocol.

Results: Dengue patients were more likely to have larger arterioles (154.78 vs 146.12, p < 0.001), higher arteriole fractal dimension (1276.16 vs 1246.11, p < 0.001), higher venule fractal dimension (1272.89 vs 1227.21, p < 0.001), more tortuous arterioles (7.45 vs 5.39, p < 0.001) and venules (8.56 vs 6.55, p < 0.001), compared to healthy controls. Resolution of infection coincided with normalization of retinal venular size, arteriole and venule fractal dimensions. Change in retinal venular size was associated with hemoglobin level (p = 0.047), while change in venular tortuosity was associated with the total white cell count (p = 0.011).

Conclusions: Changes in retinal vasculature are associated with Dengue infection and changes in hematological parameters.

Keywords: 688 retina • 550 imaging/image analysis: clinical • 636 pathobiology  
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