April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Prevalence of Age-Related Macular Degeneration in Chinese-American Adults: The Chinese American Eye Study (CHES)
Author Affiliations & Notes
  • Farzana Choudhury
    Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, CA
  • Rohit Varma
    Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, CA
  • Sardius Chen
    New York Medical College, New York, NY
  • Shaung Wu
    Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, CA
  • Chunyi Hsu
    Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, CA
  • Mina Torres
    Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, CA
  • Roberta McKean-Cowdin
    Department of Preventive Medicine, University of Southern California, Los Angeles, CA
  • Ronald Klein
    Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI
  • Stanley Paul Azen
    Department of Preventive Medicine, University of Southern California, Los Angeles, CA
  • Footnotes
    Commercial Relationships Farzana Choudhury, None; Rohit Varma, None; Sardius Chen, None; Shaung Wu, None; Chunyi Hsu, None; Mina Torres, None; Roberta McKean-Cowdin, None; Ronald Klein, None; Stanley Azen, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 667. doi:
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      Farzana Choudhury, Rohit Varma, Sardius Chen, Shaung Wu, Chunyi Hsu, Mina Torres, Roberta McKean-Cowdin, Ronald Klein, Stanley Paul Azen, ; Prevalence of Age-Related Macular Degeneration in Chinese-American Adults: The Chinese American Eye Study (CHES). Invest. Ophthalmol. Vis. Sci. 2014;55(13):667.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To determine the age- and gender- specific prevalence of age-related macular degeneration (AMD) in Chinese Americans, aged 50 years or more.

 
Methods
 

The Chinese-American Eye Study (CHES) is a population-based cross-sectional study of eligible Chinese-American participants living in Monterey Park, California. The participants underwent comprehensive eye examination, including detailed retinal photography of both eyes. Fundus photographs were graded for drusen, retinal pigmentation abnormalities, and evaluated for AMD using a modified Wisconsin Age-Related Maculopathy Grading Scale. Main outcome measures were prevalence of early and advanced AMD, drusen, geographic atrophy and exudative AMD.

 
Results
 

Of the 4,582 participants 4,172 participants (91%) had at least one gradable fundus photograph. The mean age of the participants was 61.2 years (± 8.8). Prevalence of early AMD increased from 5.9 % in those 50-59 years of age to 18.6% in those 80 years of age or older; retinal pigment abnormalities from 4.1% to 7.2%, large drusen (> 125um) from 9.8% to 32.4%, soft drusen from 27.6% to 58.6%, and soft indistinct drusen from 3.7% to 15.2%. Late AMD prevalence was 0.2% in those 50-59 years old and increasing to 1.0% in participants 80 years or older. Males had a higher prevalence of early AMD (10.2% vs 5.7%; p <0.001) and advanced AMD (0.7% vs 0.2%; p=0.02). Of 14 detected cases of late AMD, 12 were exudative AMD and 2 were cases of geographic atrophy

 
Conclusions
 

Chinese Americans in Los Angeles have a higher prevalence of early AMD, advanced AMD, and large drusen compared to previous studies in urban/rural Beijing and rural Handan. Compared to a study of urban-dwelling participants in Shihpai, Taiwan, Chinese-Americans have a comparable prevalence.

 
Keywords: 463 clinical (human) or epidemiologic studies: prevalence/incidence • 412 age-related macular degeneration  
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