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Jong Chul Han, Da Ye Choi, Young Kwun, Changwon Kee; Evaluation of lamina cribrosa thickness using spectral-domain optical coherent tomography in ocular hypertension. Invest. Ophthalmol. Vis. Sci. 2014;55(13):901.
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To evaluate the difference of lamina cribrosa thickness (LCT) and anterior lamina depth (ALD) between ocular hypertension and normal control
This was a retrospective case control study comprising 46 ocular hypertension patients and 30 healthy normal control who had undergone enhanced depth imaging optical coherence tomography (EDI-OCT) between Jan 1st and July 31th in 2013. Factors analyzed included age, intraocular pressure (IOP), central corneal thickness (CCT), spherical equivalent, LCT and ALD. Statistical analysis was performed after IOP modification based on the CCT. Provided that 530 µm of CCT is the reference standard of CCT, 3 mmHg per 50 µm of CCT was corrected for IOP modification .
No significant difference was found in IOP, CCT, spherical equivalent, LCT and ALD between ocular hypertension and normal control before and after IOP modification. In case of the patients of ocular hypertension over 24 mmHg, they had significantly thicker lamina cribrosa (258.5 ± 31.8 µm) than normal control (238 ± 28.6 µm) (p =0.04).
Ocular hypertension patients with modified IOP over 24 mmHg have thicker lamina cribrosa thickness than normal control. Thicker LCT may protect the development of glaucoma in ocular hypertension patients.
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