April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
In vivo imaging of lamina cribrosa defects in eyes with distinct patterns of glaucomatous retinal nerve fiber layer damage
Author Affiliations & Notes
  • KoEun Kim
    Ophthalmology, Seoul National University College of Medicine, Seoul, Republic of Korea
    Ophthalmology, Seoul National University Hospital, Seoul, Republic of Korea
  • Jin Wook Jeoung
    Ophthalmology, Seoul National University College of Medicine, Seoul, Republic of Korea
    Ophthalmology, Seoul National University Hospital, Seoul, Republic of Korea
  • Young Kook Kim
    Ophthalmology, Seoul National University College of Medicine, Seoul, Republic of Korea
    Ophthalmology, Seoul National University Hospital, Seoul, Republic of Korea
  • Bo Ram Seol
    Ophthalmology, Seoul National University College of Medicine, Seoul, Republic of Korea
    Ophthalmology, Seoul National University Hospital, Seoul, Republic of Korea
  • Ki Ho Park
    Ophthalmology, Seoul National University College of Medicine, Seoul, Republic of Korea
    Ophthalmology, Seoul National University Hospital, Seoul, Republic of Korea
  • Dong Myung Kim
    Ophthalmology, Seoul National University College of Medicine, Seoul, Republic of Korea
    Ophthalmology, Seoul National University Hospital, Seoul, Republic of Korea
  • Footnotes
    Commercial Relationships KoEun Kim, None; Jin Wook Jeoung, None; Young Kook Kim, None; Bo Ram Seol, None; Ki Ho Park, None; Dong Myung Kim, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 903. doi:
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      KoEun Kim, Jin Wook Jeoung, Young Kook Kim, Bo Ram Seol, Ki Ho Park, Dong Myung Kim; In vivo imaging of lamina cribrosa defects in eyes with distinct patterns of glaucomatous retinal nerve fiber layer damage. Invest. Ophthalmol. Vis. Sci. 2014;55(13):903.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To investigate the frequency of focal abnormalities in lamina cribrosa (LC) in eyes with distinct patterns of glaucomatous retinal nerve fiber layer (RNFL) damage using swept-source optical coherence tomography (SS-OCT).

Methods: One hundred and ninety-six eyes of 119 subjects with localized RNFL defects, 34 eyes of 23 subjects with diffuse RNFL defects, and 174 eyes of 109 healthy subjects were reviewed. All subjects underwent stereoscopic optic disc photography and in vivo LC imaging using a 3-dimensional optic disc scanning protocol with a prototype SS-OCT (Topcon, Inc., Tokyo, Japan). Two masked graders evaluated serial en face images and 12 radial B-scans to detect focal LC defects.

Results: In eyes with localized RNFL defects, the proportion of eyes with ≥1 LC defect was 61.7%, which was significantly higher than that with diffuse RNFL defects (23.5%) and without any RNFL defects (9.2%; all P <0.001). A total of 187 focal LC defects were found in eyes with localized RNFL defects (1.0 LC defect/eye), 10 in eyes with diffuse RNFL defects (0.3 LC defect/eye), and 17 in healthy eyes (0.1 LC defect/eye).

Conclusions: Focal LC defects were more frequently visible in eyes with localized RNFL defects than those with diffuse RNFL defects. Further investigations are needed to elucidate the pathogenic role of focal LC abnormalities in distinct patterns of glaucomatous RNFL damage.

Keywords: 577 lamina cribrosa • 550 imaging/image analysis: clinical • 610 nerve fiber layer  
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