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Won Hyuk Oh, Young Tae Kong, Seok Hwan Kim; Inter-eye Differences in Bilaterally Myopic Patients with Unilateral Normal-tension Glaucoma. Invest. Ophthalmol. Vis. Sci. 2014;55(13):922.
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To evaluate the inter-eye differences in bilaterally myopic patients with unilateral normal-tension glaucoma (NTG).
Bilaterally myopic patients with unilateral NTG were consecutively enrolled. Both eyes of each individual were compared with regard to intraocular pressure (IOP), spectral-domain optical coherence tomography parameters (circumpapillary retinal nerve fiber layer [cpRNFL] thickness, disc area, and β-zone parapapillary atrophy [PPA] area), refractive error, and axial length (AL).
Thirty-six bilaterally myopic patients with unilateral NTG were included. The untreated mean and highest IOP of NTG eyes were not significantly different from those of contralateral non-glaucomatous eyes (p = 0.837; p = 0.908, respectively). Average, superior and inferior quadrants of cpRNFL thickness in NTG eyes were thinner than those obtained for contralateral non-glaucomatous eyes (p = 0.000; p = 0.000; p = 0.000, respectively). Compared with contralateral non-glaucomatous eyes, NTG eyes exhibited reduced disc areas (1.91 ± 0.54 vs. 2.02 ± 0.50 mm2, p = 0.040), but the β-zone PPA areas in NTG eyes were larger (1.40 ± 0.75 vs. 0.98 ± 0.56 mm2, p = 0.000). NTG eyes had more myopic refractive error and longer AL than contralateral non-glaucomatous eyes (-5.73 ± 1.87 vs. -4.92 ± 2.01 D, p = 0.000; 26.42 ± 1.04 vs. 26.08 ± 1.11 mm, p = 0.000).
In myopic individuals, NTG eyes had longer AL, more myopic refractive error and larger β-zone PPA areas than contralateral non-glaucomatous eyes. Inter-eye AL differences may contribute to the development of NTG in myopes.
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