April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Factors Associated with Anterior Chamber Volume and Iris Volume in Pigment Dispersion Syndrome
Author Affiliations & Notes
  • Ruojin Ren
    Moise and Chella Safra Advanced Ocular Imaging Laboratory, Einhorn Clinical Research Center, New York Eye and Ear Infirmary of the Mount Sinai Health System, New York, NY
  • Christopher C Teng
    Moise and Chella Safra Advanced Ocular Imaging Laboratory, Einhorn Clinical Research Center, New York Eye and Ear Infirmary of the Mount Sinai Health System, New York, NY
    Department of Ophthalmology, New York Medical College, Valhalla, NY
  • Sung Chul Park
    Moise and Chella Safra Advanced Ocular Imaging Laboratory, Einhorn Clinical Research Center, New York Eye and Ear Infirmary of the Mount Sinai Health System, New York, NY
    Department of Ophthalmology, New York Medical College, Valhalla, NY
  • Mugen Liu
    Moise and Chella Safra Advanced Ocular Imaging Laboratory, Einhorn Clinical Research Center, New York Eye and Ear Infirmary of the Mount Sinai Health System, New York, NY
  • Lam Lu
    Moise and Chella Safra Advanced Ocular Imaging Laboratory, Einhorn Clinical Research Center, New York Eye and Ear Infirmary of the Mount Sinai Health System, New York, NY
  • Gustavo V De Moraes
    Moise and Chella Safra Advanced Ocular Imaging Laboratory, Einhorn Clinical Research Center, New York Eye and Ear Infirmary of the Mount Sinai Health System, New York, NY
    Department of Ophthalmology, New York University School of Medicine, New York, NY
  • Jeffrey M Liebmann
    Moise and Chella Safra Advanced Ocular Imaging Laboratory, Einhorn Clinical Research Center, New York Eye and Ear Infirmary of the Mount Sinai Health System, New York, NY
    Department of Ophthalmology, New York University School of Medicine, New York, NY
  • Robert Ritch
    Moise and Chella Safra Advanced Ocular Imaging Laboratory, Einhorn Clinical Research Center, New York Eye and Ear Infirmary of the Mount Sinai Health System, New York, NY
    Department of Ophthalmology, New York Medical College, Valhalla, NY
  • Footnotes
    Commercial Relationships Ruojin Ren, None; Christopher Teng, None; Sung Chul Park, None; Mugen Liu, None; Lam Lu, None; Gustavo De Moraes, None; Jeffrey Liebmann, Allergan, Inc. (C), Bausch & Lomb, Inc. (C), Carl Zeiss Meditech, Inc. (F), Diopysis, inc. (C), Heidelberg Engineering, GmbH (C), Heidelberg Engineering, GmbH (F), Merz Phamaceuticals, Inc. (C), National Institute of Health (F), National Institutes of Health (F), New York Glaucoma Research Institute (F), New York Glaucoma Research Institute Alcon, Inc (C), Optovue, inc. (F), Quark Pharmaceuticals, Inc. (F), Reichert, Inc. (F), Sensimed, Inc. (F), Topcon, Inc. (F), Valeant Pharmaceutiicals, Inc. (C); Robert Ritch, None
  • Footnotes
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Investigative Ophthalmology & Visual Science April 2014, Vol.55, 923. doi:
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      Ruojin Ren, Christopher C Teng, Sung Chul Park, Mugen Liu, Lam Lu, Gustavo V De Moraes, Jeffrey M Liebmann, Robert Ritch; Factors Associated with Anterior Chamber Volume and Iris Volume in Pigment Dispersion Syndrome. Invest. Ophthalmol. Vis. Sci. 2014;55(13):923.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To investigate clinical factors associated with anterior chamber volume (ACV) and iris volume (IV) in eyes with pigment dispersion syndrome (PDS) with and without ocular hypertension or glaucoma (PG) using swept-source optical coherence tomography (SS-OCT).

 
Methods
 

In this cross-sectional study, each participant underwent SS-OCT (Casia SS-1000 OCT; Tomey, Inc., Nagoya, Japan) to obtain 128 volumetric high-resolution radial B-scans centered on the pupil center and a complete ophthalmologic examination including standard automated perimetry (SAP) and spectral-domain OCT retinal nerve fiber layer thickness (RNFLT). Trace lines of the anterior chamber and iris contour were reviewed by a glaucoma specialist and corrected if necessary. ACV and IV were analyzed using the SS-OCT’s built-in software. ACV and IV were correlated with the following demographic and clinical factors using a multivariate model: age, phakic refractive error, untreated intraocular pressure (IOP), central cornea thickness (CCT), SAP mean deviation (MD) and RNFLT.

 
Results
 

20 eyes (10 patients; 4 women; mean age, 43±12 years), including 7 PDS eyes and 13 PG eyes, were included. Mean refractive error, central corneal thickness, and SAP mean deviation were -2.56±2.34D, 556.8±27.3µm, and -2.44±3.24dB, respectively (Table 1). Mean ACV was 239±29 mm3 (range, 194-297) and mean iris volume was 44±5 mm3 (range, 37 -54). Greater ACV was associated with higher IOP (p=0.03) and associated with worse SAP MD (p=0.04) and lower CCT (p=0.04). IV was not related to these factors (all p>0.05).

 
Conclusions
 

Greater ACV appears to be greater with higher IOP and worse visual field status in PDS and PG eyes. Greater ACV may be related to more frequent or wider iridozonular contact and enhanced pigment liberation.

  
Keywords: 550 imaging/image analysis: clinical  
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