April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Anterior segment OCT and confocal microscopy can be predictive of the bleb failure of a new minimally invasive glaucoma surgery technique, the XEN implant (Aquesys)?
Author Affiliations & Notes
  • Giulia Consolandi
    Università degli Studi di Torino, Torino, Italy
  • Antonio Maria Fea
    Università degli Studi di Torino, Torino, Italy
  • Carlo Alessandro Lavia
    Università degli Studi di Torino, Torino, Italy
  • Giulia Pignata
    Università degli Studi di Torino, Torino, Italy
  • Paola Maria Loredana Cannizzo
    Università degli Studi di Torino, Torino, Italy
  • Francesco Gallozzi
    Università degli Studi di Torino, Torino, Italy
  • Roberta Spinetta
    Università degli Studi di Torino, Torino, Italy
  • Teresa Rolle
    Università degli Studi di Torino, Torino, Italy
  • Federico M Grignolo
    Università degli Studi di Torino, Torino, Italy
  • Footnotes
    Commercial Relationships Giulia Consolandi, None; Antonio Fea, None; Carlo Alessandro Lavia, None; Giulia Pignata, None; Paola Maria Loredana Cannizzo, None; Francesco Gallozzi, None; Roberta Spinetta, None; Teresa Rolle, None; Federico Grignolo, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 942. doi:
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      Giulia Consolandi, Antonio Maria Fea, Carlo Alessandro Lavia, Giulia Pignata, Paola Maria Loredana Cannizzo, Francesco Gallozzi, Roberta Spinetta, Teresa Rolle, Federico M Grignolo; Anterior segment OCT and confocal microscopy can be predictive of the bleb failure of a new minimally invasive glaucoma surgery technique, the XEN implant (Aquesys)?. Invest. Ophthalmol. Vis. Sci. 2014;55(13):942.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

Most of the minimally invasive glaucoma surgery (MIGS) procedures address the angle or the suprachoroidal space by the use of new implants (Glaukos, Ivantis, Transcend, MidiArrow) but their proper placement and the patency of the outflow pathways remains a matter of clinical experience. Aim of the study was to investigate if anterior segment OCT and confocal microscopy could add clinical informations of the long term health of the bleb obtained using a new collagen derived implant (XEN).

 
Methods
 

The device was implanted in 10 POAG patients (8 males/ 2 females, 64,5 mean age ±12,93 SD). IOP with GAT, AS-OCT (RTVue, Optovue), confocal microscopy (Heidelberg) were assessed one day, 1 week, 1 month and 6 months post-operatively. At the same time points, bleb morphology was evaluated by two masked observers. The bleb was defined as present, encapsulated, cystic or absent. The position and the presence of fluid were evaluated using the AS-OCT. The presence of subconjunctival cystic spaces was assessed by the confocal microscopy. Complete success was defined as mean diurnal IOP<18 mm Hg and qualified success as mean diurnal IOP<18 mm Hg on medication.

 
Results
 

Direct communication between the anterior chamber and the subconjunctival space was demonstrated in all patients intraoperatively by obtaining a bleb after intracameral injection of BSS. Mean IOP 1 day post-operatively was 14 mmHg (17 mmHg less than pre-operatively medicated IOP). The bleb was defined as present in all patients at 1 month by both observers. The track of the implant could be visualized using the AS-OCT . Subconjunctival fluid on OCT (fig.1) and cystic spaces on confocal microscopy could be demonstrated in 8 and 4 patients respectively at 1 month (fig.2). The 6 patients in which there was no evidence of subconjunctival cystic spaces at one month (fig 5), failed at 6 months.

 
Conclusions
 

This new MIGS implant present the advantage of allowing direct intraoperative assessment of the outflow from the anterior chamber to the subconjunctival space. AS OCT can be used in the immediate post-operative period to determine the correct position of the implant and the presence of subconjunctival fluid. The presence of conjunctival cysts assessed by confocal microscopy seems a predictive factor of medium term failure of the bleb.

     
Keywords: 568 intraocular pressure • 550 imaging/image analysis: clinical • 596 microscopy: confocal/tunneling  
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