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Youngdon Kim, Seung Jae Lee, Haksu Kyung; Analysis of visual field defect according to RNFL thickness in Korean glaucoma patients. Invest. Ophthalmol. Vis. Sci. 2014;55(13):946.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the correlation between retinal nerve fiber layer(RNFL) thickness and visual field of korean glaucoma patients using SD-OCT and Humphrey visual field(HVF) test.
114 patients, 205 eyes, diagnosed with normal tension glaucoma(NTG), ocular hypertension(OHT) or primary open angle glaucoma(POAG) were enrolled. Subjects were divided into two groups by average RNFL thickness; - Thinner group(70µm or thinner) and thicker group(thicker than 70µm). Their average RNFL thickness measured by SD-OCT and mean deviation(MD) of HVF test, which were performed at same day, were analyzed to evaluate their correlation.
162 eyes were available at both two tests. There was a significant correlation between average RNFL thickness and MD(r= 0.57; p=0.00). Thinner group consisted of 45 eyes and thicker group consisted of 117 eyes. In thicker group, MD was well correlated with average RNFL thickness(r= 0.29; p=0.002). In thinner group, there was a borderline correlation between MD and average RNFL thickness(r=0.27; p=0.076). But, MD of thinner group was more dependent to the change of average RNFL thickness than that of thicker group(thinner group: regression coefficient= 0.43, thicker group: regression coefficient=0.15).
There was a significant correlation between average RNFL thickness and MD of HVF test. In advanced glaucoma with thinner average RNFL thickness, visual field defect was more susceptible to the change of RNFL thickness than early glaucoma
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