April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Retinal Ganglion Cells Count and Structure/Function Correlation in Glaucoma
Author Affiliations & Notes
  • Giovanni Milano
    University Eye Clinic, University of Pavia, Pavia, Italy
    Ophthalmology, Fondazione I.R.C.C.S. Policlinico San Matteo, Pavia, Italy
  • Pietro Distante
    University Eye Clinic, University of Pavia, Pavia, Italy
  • Alice Chandra Verticchio Vercellin
    University Eye Clinic, University of Pavia, Pavia, Italy
    Ophthalmology, Fondazione I.R.C.C.S. Policlinico San Matteo, Pavia, Italy
  • Sara Lombardo
    University Eye Clinic, University of Pavia, Pavia, Italy
    Ophthalmology, Fondazione I.R.C.C.S. Policlinico San Matteo, Pavia, Italy
  • Sara Lanteri
    University Eye Clinic, University of Pavia, Pavia, Italy
    Ophthalmology, Fondazione I.R.C.C.S. Policlinico San Matteo, Pavia, Italy
  • Marta Raimondi
    University Eye Clinic, University of Pavia, Pavia, Italy
    Ophthalmology, Fondazione I.R.C.C.S. Policlinico San Matteo, Pavia, Italy
  • Massimiliano Rolando
    University Eye Clinic, University of Pavia, Pavia, Italy
    Ophthalmology, Fondazione I.R.C.C.S. Policlinico San Matteo, Pavia, Italy
  • Carmine Tinelli
    Ophthalmology, Fondazione I.R.C.C.S. Policlinico San Matteo, Pavia, Italy
  • Footnotes
    Commercial Relationships Giovanni Milano, None; Pietro Distante, None; Alice Chandra Verticchio Vercellin, None; Sara Lombardo, None; Sara Lanteri, None; Marta Raimondi, None; Massimiliano Rolando, None; Carmine Tinelli, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 959. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Giovanni Milano, Pietro Distante, Alice Chandra Verticchio Vercellin, Sara Lombardo, Sara Lanteri, Marta Raimondi, Massimiliano Rolando, Carmine Tinelli; Retinal Ganglion Cells Count and Structure/Function Correlation in Glaucoma. Invest. Ophthalmol. Vis. Sci. 2014;55(13):959.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: To analyze the correlation between structural and functional parameters obtained by SD-OCT and Standard Automated Perimetry (SAP) and retinal ganglion cells (RGC) count, estimated applying an empirical model by Medeiros et al. in glaucoma patients

Methods: A sample of 89 eyes of 47 consecutive patients suspected for or affected by primary open angle glaucoma were selected. They were submitted to SITA Standard 24-2 program and staged according to Glaucoma Staging System 2 on the basis of Mean Defect (MD) and Pattern Standard Deviation (PSD). Three groups were created: group 0 (Stage 0 and borderline), group 1 (Stages 1 and 2) and group 2 (Stages 3, 4 and 5). All the eyes were scanned with iVue SD-OCT system using ONH and GCC scan pattern. RNFL total and sectorial (superior, inferior, temporal), GCC total, superior and inferior thicknesses were considered. RNFL temporal is the mean of all temporal sectors. Estimates of RGC count were obtained in circumpapillary and in macular regions from OCT and SAP data according to the empirical model. The 16 central points corresponding to GCC scanned area were considered as macular region of each visual field

Results: MD and PSD always show statistically significant difference (p < 0,01) comparing the three groups. Nevertheless VFI, RNFL and GCC show p > 0,01 comparing groups 0 and 1 with the exception of RNFL Temporal showing a substantial thinning between group 0 (99,64±14,03 μm) and group 1 (77,43±15,51 μm). RGC estimates seem to be able to discriminate patients at different stages of neuropathy. A good correlation exists between parameters obtained with the same algorithm (SAP or OCT) and also between the two structural algorithms (RNFL and GCC). A moderate correlation has been demonstrated between structural and functional parameters

Conclusions: SAP is nowadays considered the clinical standard for diagnosis and follow-up of glaucoma. RNFL and GCC are not much better than VFI in discerning between a substantial normality and a very early disease. Moderate correlation between functional and structural parameters is surely interesting considering all the differences between SAP and OCT. Estimates RGC counts are useful to discriminate between the three groups and they correlate in a very good way with structural and functional parameters

Keywords: 531 ganglion cells • 550 imaging/image analysis: clinical • 642 perimetry  
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×