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Takuya Numata, Chota Matsumoto, Sachiko Okuyama, Sonoko Takada, Fumi Tanabe, Shigeki Hashimoto, Mariko Eura, Tomoyasu Kayazawa, Eiko Arimura-Koike, Yoshikazu Shimomura; High resolution perimetry with 0.5 degree interval and its correspondence to GCL+IPL thickness. Invest. Ophthalmol. Vis. Sci. 2014;55(13):960.
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© ARVO (1962-2015); The Authors (2016-present)
Visual field testing was performed using high resolution perimetry with 0.5 degree interval to investigate its correspondence to retinal structural images presented by OCT.
Ten eyes of 10 patients with glaucoma (mean age: 61.7±6.6) and 10 eyes of 10 normal subjects (mean age: 63.5±2.7) were studied. Octopus 900 Custom test program was used with target size III and background luminance of 31.4 asb. The test points were placed from the fixation point to the eccentricity of 30 degrees on the upper temporal meridian of 45 degrees with 0.5 degree interval and the sensitivity was evaluated three times at each point. The blind spot was detected using Octopus 900 Custom test with 1 degree interval grid pattern. The corresponding retinal structure was examined using Cirrus HD-OCT with HD 5 Line Raster (1 line), 9 mm, High Definition Images. The visual field was superimposed on the OCT image by matching the blind spot to the optic disc and the fovea to the fixation point. The ganglion cell layer (GCL) + inner plexiform layer (IPL) thickness corresponding to each point was measured manually. Within the eccentricity of 7 degrees, the location of the point was adjusted to correspond to the location of the retinal ganglion cell, taking into account its displacement near the fovea. The correspondence of sensitivity to GCL+IPL thickness was investigated.
The GCL+IPL thickness measured more than 24.3 μm even at the area where the sensitivity was 0 dB in our glaucoma cases. In the eccentricity of more than 6.7 degrees, the dynamic range of GCL+IPL thickness was narrow, therefore the GCL+IPL thickness couldn’t evaluate the difference of sensitivity. In the eccentricity of 6.7 degrees or less, the dynamic range of GCL+IPL thickness was wide in normal subjects. In this area, functional changes were mostly corresponded with structural changes. However, we also detected the functional changes preceded structural changes and the structural changes preceded functional changes.
In the eccentricity of more than 6.7 degrees, the sensitivity loss was not reflected in the change of GCL+IPL thickness.
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