April 2014
Volume 55, Issue 13
Free
ARVO Annual Meeting Abstract  |   April 2014
Enhanced Structure-Function Relationship in Glaucoma with an Anatomically and Geometrically Accurate Neuroretinal Rim Measurement
Author Affiliations & Notes
  • Vishva M Danthurebandara
    Ophthalmology and Visual Sciences, Dalhousie University, Halifax, NS, Canada
  • Glen P Sharpe
    Ophthalmology and Visual Sciences, Dalhousie University, Halifax, NS, Canada
  • Donna M Hutchison
    Ophthalmology and Visual Sciences, Dalhousie University, Halifax, NS, Canada
  • Jonathan Denniss
    Optometry and Vision Sciences, The University of Melbourne, Melbourne, VIC, Australia
    Computing and Information Systems, The University of Melbourne, Melbourne, VIC, Australia
  • Marcelo T Nicolela
    Ophthalmology and Visual Sciences, Dalhousie University, Halifax, NS, Canada
  • Allison M McKendrick
    Optometry and Vision Sciences, The University of Melbourne, Melbourne, VIC, Australia
  • Andrew Turpin
    Computing and Information Systems, The University of Melbourne, Melbourne, VIC, Australia
  • Balwantray C Chauhan
    Ophthalmology and Visual Sciences, Dalhousie University, Halifax, NS, Canada
  • Footnotes
    Commercial Relationships Vishva Danthurebandara, None; Glen Sharpe, None; Donna Hutchison, None; Jonathan Denniss, Heidelberg Engineering (F); Marcelo Nicolela, None; Allison McKendrick, Heidelberg Engineering (F); Andrew Turpin, Haag-Streit (F), Heidelberg Engineering (F); Balwantray Chauhan, Heidelberg Engineering (C), Heidelberg Engineering (F)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science April 2014, Vol.55, 963. doi:
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    • Get Citation

      Vishva M Danthurebandara, Glen P Sharpe, Donna M Hutchison, Jonathan Denniss, Marcelo T Nicolela, Allison M McKendrick, Andrew Turpin, Balwantray C Chauhan; Enhanced Structure-Function Relationship in Glaucoma with an Anatomically and Geometrically Accurate Neuroretinal Rim Measurement. Invest. Ophthalmol. Vis. Sci. 2014;55(13):963.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose
 

To determine whether the relationship between the visual field (VF) and the standard optic disc margin based rim area (DM-RA) could be improved by using the Bruch's membrane opening based minimum rim width (BMO-MRW), an anatomically and geometrically accurate optic nerve head (ONH) parameter.

 
Methods
 

Structure-function relationships were determined in one eye of 151 glaucoma patients tested with automated perimetry, confocal scanning laser tomography (CSLT) and spectral domain optical coherence tomography (SD-OCT, Spectralis) on the same day. SD-OCT images of the ONH with 24 radial B-scans were acquired conventionally, relative to a fixed coordinate system (acquired image frame, AIF), and also relative to the eye-specific fovea-BMO centre (FoBMO) axis. Variables examined were visual field (VF) sensitivity, DM-RA (obtained with CSLT), BMO-MRWAIF and BMO-MRWFoBMO. VF locations were mapped to ONH sectors with fixed Garway-Heath maps, VFGH (Garway-Heath et al., 2000), a method commonly used for assessing structure-function relationships, and with patient-specific maps customized for a series of biometric parameters, VFPS (Denniss et al., 2012).

 
Results
 

Globally and regionally, the relationship between BMO-MRWFoBMO and VFPS was significantly stronger than that between DM-RA and VFGH (Fig. 1). The R2 for the relationship between BMO-MRWFoBMO and VFPS (in linear scale, 1/L) ranged from 5% (nasal) to 31% (inferotemporal) while that between DM-RA and VFGH ranged from 0.3% (inferonasal) to 11% (superotemporal). The R2 between BMO-MRWAIF and VFGH ranged from 5% (nasal) to 30% (inferotemporal), indicating that the structure-function relationship did not improve significantly with data acquisition and analysis in FoBMO coordinates (Fig. 2). Further, the impact of customized VF mapping was modest as the R2 corresponding to the relationship between BMO-MRWFoBMO and VFGH [ranging 5% (nasal) to 30% (inferotemporal)] was not significantly different from that between BMO-MRWFoBMO and VFPS.

 
Conclusions
 

The structure-function relationship enhanced significantly with BMO-MRW, likely because of its anatomical and geometric accuracy. While the clinical utility of customized VF mapping and FoBMO image acquisition in individual subjects is likely high, due to the relatively large sectors used conventionally, their impact on improving the structure-function relationship was marginal.

     
Keywords: 552 imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • 758 visual fields • 627 optic disc  
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