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Takeshi Ono, Naoki Ozeki, Daisuke Shiba, Kenya Yuki, Kazuo Tsubota, ; Relationship Between Within-eye Asymmetry of Relative Afferent Pupillary Defect with Pupillography and Ganglion Cell Complex Thickness by Optical Coherence Tomography in Asymmetric Glaucoma. Invest. Ophthalmol. Vis. Sci. 2014;55(13):977.
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To evaluate association between within-eye asymmetry (superonasal versus inferonasal) of relative afferent pupillary defect (RAPD) with pupillography and corresponding macular ganglion cell complex thickness (MGCCT) in asymmetric glaucoma.
We used RAPDx (Konan Medical USA, USA) to evaluate RAPD. The RAPDx is designed to analyze pupil response at white stimulus intensity. This device records precise amplitude of pupil responses. Inclusion criteria were having optic disc abnormalities and visual field loss caused by glaucoma. Exclusion criteria were having retinal disease, other optic neuropathy, cornea disease, non-reactive pupils or asymmetric cataract. MGCCT was measured with spectral domain optical coherence tomography (RS-3000; Nidek, Japan). We evaluated association between within-eye asymmetry (superonasal versus inferonasal) of RAPDx amplitude and corresponding MGCCT.
82 eyes of 42 glaucoma patients (26 males, 16 females; mean age: 62.2±12.8 years; range: 28 - 88 years) were enrolled. Mean MGCCTs were 89.7 ± 13.6 (range: 54 - 114) μm in thicker semicircles and 78.2 ± 15.3 (range: 51 - 110) μm in thinner semicircles. The differences of MGCCT (thicker semicircle - thinner semicircle) were 11.5 ± 9.5 (range: 0 - 36) μm. The RAPDx amplitude within-eyes asymmetries (superonasal versus inferonasal) were 0.52 ±0.93 log units. The results of linear regression analysis between within-eye asymmetry (superonasal versus inferonasal) of RAPDx amplitude and corresponding MGCCT was R2 = 0.057 (p=0.03).
Log-scaled RAPD amplitude of white stimulus had moderate correlation to MGCCT asymmetry.
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